Anti-ANTXR2 antibody (ab113523)

Overview

  • Product nameAnti-ANTXR2 antibodySee all ANTXR2 primary antibodies ...
  • Description
    Goat polyclonal to ANTXR2
  • Tested applicationsWB, IHC-P more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Dog
  • Immunogen

    Synthetic peptide conjugated to KLH, from an internal sequence of Human ANTXR2 (NP_477520.2; NP_001139266.1).

  • Positive control
    • Human Kidney and Liver tissues; Human, Mouse and Rat Kidney lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab113523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 54 kDa).
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • FunctionNecessary for cellular interactions with laminin and the extracellular matrix.
  • Tissue specificityExpressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
  • Involvement in diseaseDefects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH) [MIM:236490]. This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures.
    Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF) [MIM:228600]. JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility.
  • Sequence similaritiesBelongs to the ATR family.
    Contains 1 VWFA domain.
  • DomainBinding to PA seems to be effected through the VWA domain.
  • Cellular localizationSecreted; Cell membrane. Expressed at the cell surface and Endoplasmic reticulum membrane. Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
  • Target information above from: UniProt accession P58335 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • 2310046B19Rik antibody
    • Anthrax toxin receptor 2 antibody
    • ANTR2_HUMAN antibody
    • Antxr2 antibody
    • AW561899 antibody
    • Capillary morphogenesis gene 2 protein antibody
    • CMG 2 antibody
    • CMG-2 antibody
    • CMG2 antibody
    • FLJ31074 antibody
    • ISH antibody
    • JHF antibody
    • MGC111533 antibody
    • MGC45856 antibody
    see all

Anti-ANTXR2 antibody images

  • Anti-ANTXR2 antibody (ab113523) at 0.3 µg/ml + Mouse Kidney lysate (in RIPA buffer) at 35 µg
    developed using the ECL technique

    Predicted band size : 54 kDa
  • ab113523, at 2.5µg/ml, staining ANTXR2 in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry.
  • ab113523, at 2.5µg/ml, staining ANTXR2 in Formalin-fixed, Paraffin-embedded Human liver tissue by Immunohistochemistry.

References for Anti-ANTXR2 antibody (ab113523)

ab113523 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Frozen sections)
Sample Mouse Tissue sections (kidney, liver)
Specification kidney, liver
Blocking step HCl or none as blocking agent for 20 minute(s) · Concentration: 0.02% · Temperature: 20°C
Fixative none
Username

Ms. Nadine Regenscheit

Verified customer

Submitted Oct 29 2013

The immunogenic peptide used to generate ab113523 is located in the extracellular region of ANTXR2.

Please do contact me if you have any additional questions.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"