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Product Name
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AP2 alpha antibody [AP2a 8G8/5]
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See all AP2 alpha - transcription factor antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [AP2a 8G8/5] to AP2 alpha
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Immunogen
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Bacterial AP2 alpha/AP2 gamma fusion protein.
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Reacts with
(species key)
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Hu
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Specificity
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Does not cross-react with AP2 beta or Ap2 gamma.
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Tested applications
(see key)
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IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 50 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Raji cells or breast carcinoma
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Cellular localization
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Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> Transcription >> Other factors
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Relevance
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Activation Protein transcription factor 2 (AP2) is a developmentally regulated transcription factor that recognizes a specific sequence CCCCAGGC or related sequences present in several promoter and enhancer gene regions including the promoters of the AP2 genes themselves. There are three different but highly homologous AP2 isoforms: alpha, beta, and gamma (ERF-1), encoded by three different retinoic acid-responsive genes. Each form of AP2 possesses the DNA binding domain (basic helix-span-helix motif) characteristic of this family of transcription factors. The AP2 proteins are normally expressed in ectodermally derived vertebrate tissues where they are necessary for normal growth and development. The factors have also been implicated in the control of cell proliferation, viral transformation, and oncogenesis. AP2 seems to play in important role in human breast cancer.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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AP2a 8G8/5
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Isotype
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IgG1
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Purity
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IgG fraction
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this AP2 alpha antibody [AP2a 8G8/5] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for AP2 alpha antibody [AP2a 8G8/5] (ab18112)
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This product has been used in:
Bennett KL et al. AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma. PLoS One 4:e6931 (2009). WB; Human. PubMed: 19742317
If you publish research using ab18112 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to AP2 alpha
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