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Anti-APAF1 antibody (ab2445)

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Overview

Product name

Anti-APAF1 antibody
See all APAF1 products (12) ...

Description

Rabbit polyclonal to APAF1

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic peptide (Human).

Positive control

HeLa and Jurkat lysate.

Properties

Form

Liquid

Storage instructions

Store at +4°C. Do not freeze.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: 0.2% Gelatin, PBS

Concentration

Concentration information loading...

Clonality

Polyclonal

Isotype

IgG

Research areas

Metabolism >> Pathways and Processes >> Metabolism processes >> Apoptosis
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Mitochondrial markers
Cancer >> Invasion/microenvironment >> Apoptosis >> Cytochrome C
Cell Biology >> Apoptosis >> Mitochondrial

Applications

Show applications key

Our Abpromise guarantee covers the use of ab2445 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

Application notes

For Western Blotting, 1:200
Optimal dilutions should be determined by the user.

Target

Function

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.

Tissue specificity

Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.

Sequence similarities

Contains 1 CARD domain.
Contains 1 NB-ARC domain.
Contains 13 WD repeats.

Domain

The CARD domain mediates interaction with APIP.

Cellular localization

Cytoplasm.

Target information above from: UniProt accessionO14727 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • APAF 1 antibody
  • Apaf-1 antibody
  • APAF_HUMAN antibody
  • Apaf1 antibody
  • Apoptotic peptidase activating factor 1 antibody
  • Apoptotic protease activating factor 1 antibody
  • Apoptotic protease activating factor antibody
  • Apoptotic protease-activating factor 1 antibody
  • CED 4 antibody
  • CED4 antibody
  • KIAA0413 antibody
see all

Database links

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References for Anti-APAF1 antibody (ab2445)

ab2445 has not yet been referenced specifically in any publications.

Publishing research using ab2445? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"