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Overview

  • Product nameAnti-APCDD1 antibodySee all APCDD1 primary antibodies ...
  • Description
    Rabbit polyclonal to APCDD1
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Chicken, Human
  • Immunogen

    Synthetic peptide derived from within residues 400-500 of Human APCDD1

  • Positive controlHuman heart lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: 30% Glycerol, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab77476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 0.5 µg/ml. Predicted molecular weight: 59 kDa.

Target

  • FunctionNegative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
  • Tissue specificityAbundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
  • Involvement in diseaseDefects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
  • Sequence similaritiesBelongs to the APCDD1 family.
  • Post-translational
    modifications    N-Glycosylated.
  • Cellular localizationCell membrane.

    • Target information above from: UniProt accession Q8J025 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Adenomatosis polyposis coli down regulated 1 antibodyAdenomatosis polyposis coli down regulated 1 protein antibodyAdenomatosis polyposis coli down-regulated 1 protein antibody
        APCD1_HUMAN antibodyAPCDD 1 antibodyAPCDD1 antibodyB7323 antibodyDRAPC1 antibodyFP7019 antibodyProtein APCDD1 antibody
      see all

    Anti-APCDD1 antibody images

    • Western blot - APCDD1 antibody (ab77476)
      Western blot - APCDD1 antibody (ab77476)
      Anti-APCDD1 antibody (ab77476) at 0.5 µg/ml + Human heart lysate

      Predicted band size : 59 kDa
      Observed band size : 59 kDa
      Additional bands at : 46 kDa,64 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-APCDD1 antibody (ab77476)

    ab77476 has not yet been referenced specifically in any publications.

    Publishing research using ab77476 ? Please let us know so that we can cite the reference in this datasheet

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    Western blot abreview for Anti-APCDD1 antibody

     Average
    Abreviews
    Application Western blot
    Sample Mouse Tissue lysate - whole (nerve)
    Loading amount 40 µg
    Specification nerve
    Gel Running Conditions Reduced Denaturing
    Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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    Submitted Jun 23 2010

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"