Overview

  • Product nameAnti-APCDD1 antibodySee all APCDD1 primary antibodies ...
  • Description
    Rabbit polyclonal to APCDD1
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Mouse, Chicken, Human
  • Immunogen

    Synthetic peptide derived from within residues 400-500 of Human APCDD1

  • Positive control
    • Human heart lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: 30% Glycerol, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab77476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 59 kDa.

Target

  • FunctionNegative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
  • Tissue specificityAbundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
  • Involvement in diseaseDefects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
  • Sequence similaritiesBelongs to the APCDD1 family.
  • Post-translational
    modifications
    N-Glycosylated.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adenomatosis polyposis coli down regulated 1 antibody
    • Adenomatosis polyposis coli down regulated 1 protein antibody
    • Adenomatosis polyposis coli down-regulated 1 protein antibody
    • APCD1_HUMAN antibody
    • APCDD 1 antibody
    • APCDD1 antibody
    • B7323 antibody
    • DRAPC1 antibody
    • FP7019 antibody
    • HHS antibody
    • HTS antibody
    • hypoptrichosis simplex antibody
    • Protein APCDD1 antibody
    see all

Anti-APCDD1 antibody images

  • Anti-APCDD1 antibody (ab77476) at 0.5 µg/ml + Human heart lysate

    Predicted band size : 59 kDa
    Observed band size : 59 kDa
    Additional bands at : 46 kDa,64 kDa. We are unsure as to the identity of these extra bands.

References for Anti-APCDD1 antibody (ab77476)

ab77476 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Sample Mouse Tissue lysate - whole (nerve)
Loading amount 40 µg
Specification nerve
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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Submitted Jun 23 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"