Anti-APH1a antibody (ab19390)

Overview

• Product nameAnti-APH1a antibodySee all APH1a primary antibodies ...
• Description
  Rabbit polyclonal to APH1a
• Tested applicationsICC/IF, IP, WB more details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  Synthetic peptide: CRRQEDSRVMVYSALRIPPED conjugated to KLH, corresponding to C terminal domain of the long isoform of amino acids 245-265 of Human APH1a.

  Run BLAST with Run BLAST with
• Positive controlMouse Brain and Kidney extract (western blot).

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.005% Sodium Azide
  Constituents: 16.6% Glycerol, PBS, 1mg/ml BSA
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Stem Cells
  • Signaling Pathways
  • Notch
  • Cytoplasmic

  • Neuroscience
  • Neurology process
  • Notch Pathway

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Parkinson's disease
  • Other

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Alzheimer's disease
  • Amyloid

Applications

Target

• FunctionEssential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
• Tissue specificityWidely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
• Sequence similaritiesBelongs to the APH-1 family.
• Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.

Target information above from: UniProt accession Q96BI3 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 51107 Human
  • Entrez Gene: 226548 Mouse
  • Omim: 607629 Human
  • SwissProt: Q5TB23 Human
  • SwissProt: Q96BI3 Human
  • SwissProt: Q3U886 Mouse
  • SwissProt: Q6GTF1 Mouse
  • SwissProt: Q8BVF7 Mouse

  • Unigene: 108408 Human
  • Unigene: 306954 Mouse

  see all

• Alternative names
  6530402N02Rik antibodyAL138795.3 antibodyAnterior Pharynx Defective 1 antibody

  Anterior pharynx defective 1 homolog A antibodyAPH 1A antibodyAph 1alpha antibodyAPH-1a antibodyAph-1alpha antibodyAph1a antibodyAPH1A_HUMAN antibodyCGI 78 antibodyCGI78 antibodyGamma secretase subunit APH 1A antibodyGamma Secretase Subunit APH1a antibodyGamma-secretase subunit APH-1A antibodyLikely ortholog of C. elegans anterior pharynx defective 1A antibodyPresenilin Stabilization Factor antibodyPresenilin-stabilization factor antibodyPSF antibodyUNQ579/PRO1141 antibody

  see all

Anti-APH1a antibody images

• 

  Western blot - APH1a antibody (ab19390)
  
  
  Predicted band size : 29 kDa
  
  
  Western blot of APH1a in mouse brain and kidney extracts using ab19390.
• 

  Immunocytochemistry/ Immunofluorescence - APH1a antibody (ab19390)
  Immunofluorescence staining of APH1a in human KNS42 glioma cells using ab19390.