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Anti-APH1a antibody (ab19390)

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Overview

Product name

Anti-APH1a antibody
See all APH1a products (6) ...

Description

Rabbit polyclonal to APH1a

Tested applications

IF, IP, WBmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

Synthetic peptide: CRRQEDSRVMVYSALRIPPED conjugated to KLH, corresponding to C terminal domain of the long isoform of amino acids 245-265 of Human APH1a.

CRRQEDSRVM VYSALRIPPE D

Positive control

Mouse Brain and Kidney extract (western blot).

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.005% Sodium Azide
Constituents: 16.6% Glycerol, PBS, 1mg/ml BSA

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

  • Western blot - APH1a antibody (ab19390)Western blot - APH1a antibody (ab19390) image (enlarge)

  • Immunocytochemistry/ Immunofluorescence - APH1a antibody (ab19390)Immunocytochemistry/ Immunofluorescence - APH1a antibody (ab19390) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab19390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IF

     IF: 1/100

    IF: 1/100

  • ShowHide

    IP

     IP: Use at an assay depe...Read more →

    IP: Use at an assay dependent dilution.

  • ShowHide1 Image

    WB

     WB: 1/1000Detects a band...Read more →

    WB: 1/1000Detects a band of approximately 18 kDa (predicted molecular weight: 29 kDa).

Target

Function

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

Tissue specificity

Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.

Sequence similarities

Belongs to the APH-1 family.

Cellular localization

Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.

Target information above from: UniProt accessionQ96BI3 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • 6530402N02Rik antibody
  • AL138795.3 antibody
  • Anterior Pharynx Defective 1 antibody
  • Anterior pharynx defective 1 homolog A antibody
  • APH 1A antibody
  • Aph 1alpha antibody
  • APH-1a antibody
  • Aph-1alpha antibody
  • Aph1a antibody
  • APH1A_HUMAN antibody
  • CGI 78 antibody
  • CGI78 antibody
  • Gamma secretase subunit APH 1A antibody
  • Gamma Secretase Subunit APH1a antibody
  • Gamma-secretase subunit APH-1A antibody
  • Likely ortholog of C. elegans anterior pharynx defective 1A antibody
  • Presenilin Stabilization Factor antibody
  • Presenilin-stabilization factor antibody
  • PSF antibody
  • UNQ579/PRO1141 antibody
see all

Anti-APH1a antibody images:

  Western blot - APH1a antibody (ab19390)

Western blot - APH1a antibody (ab19390)



Predicted band size : 29 kDa


Western blot of APH1a in mouse brain and kidney extracts using ab19390.

  Immunocytochemistry/ Immunofluorescence - APH1a antibody (ab19390)

Immunocytochemistry/ Immunofluorescence - APH1a antibody (ab19390)

Immunofluorescence staining of APH1a in human KNS42 glioma cells using ab19390.

References for Anti-APH1a antibody (ab19390)

ab19390 has not yet been referenced specifically in any publications.

Publishing research using ab19390? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"