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Products:Neuroscience >> Neurology process >> Notch Pathway
Overview
Product name
Anti-APH1a antibody
See all APH1a products (6) ...
Description
Rabbit polyclonal to APH1a
Tested applications
IF, IP, WBmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide: CRRQEDSRVMVYSALRIPPED conjugated to KLH, corresponding to C terminal domain of the long isoform of amino acids 245-265 of Human APH1a.
CRRQEDSRVM VYSALRIPPE D
Positive control
Mouse Brain and Kidney extract (western blot).
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.005% Sodium Azide
Constituents: 16.6% Glycerol, PBS, 1mg/ml BSA
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Stem Cells >> Signaling Pathways >> Notch >> Cytoplasmic
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Amyloid
Neuroscience >> Neurology process >> Neurodegenerative disease >> Parkinson's disease >> Other
Neuroscience >> Neurology process >> Notch Pathway
Applications
Show applications key
Our Abpromise guarantee covers the use of ab19390 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IF
IF: 1/100IF: 1/100
IP: Use at an assay dependent dilution.
WB: 1/1000Detects a band of approximately 18 kDa (predicted molecular weight: 29 kDa).
Target
Function
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Tissue specificity
Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
Sequence similarities
Belongs to the APH-1 family.
Cellular localization
Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Target information above from: UniProt accessionQ96BI3
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 6530402N02Rik antibody
- AL138795.3 antibody
- Anterior Pharynx Defective 1 antibody
see all
Database links
- Entrez Gene: 51107 Human
- Entrez Gene: 226548 Mouse
- Omim: 607629 Human
- SwissProt: Q5TB23 Human
- SwissProt: Q96BI3 Human
- SwissProt: Q3U886 Mouse
- SwissProt: Q6GTF1 Mouse
- SwissProt: Q8BVF7 Mouse
see all
Anti-APH1a antibody images:
Western blot - APH1a antibody (ab19390)
Predicted band size : 29 kDa
Western blot of APH1a in mouse brain and kidney extracts using ab19390.
Immunocytochemistry/ Immunofluorescence - APH1a antibody (ab19390)
Immunofluorescence staining of APH1a in human KNS42 glioma cells using ab19390.
References for Anti-APH1a antibody (ab19390)
ab19390 has not yet been referenced specifically in any publications.
Publishing research using ab19390? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"