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Overview

  • Product nameAnti-APH1a antibodySee all APH1a primary antibodies ...
  • Description
    Rabbit polyclonal to APH1a
  • Tested applicationsICC/IF, IP, WB more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide: CRRQEDSRVMVYSALRIPPED conjugated to KLH, corresponding to C terminal domain of the long isoform of amino acids 245-265 of Human APH1a.

  • Positive controlMouse Brain and Kidney extract (western blot).

Properties

Applications

Our Abpromise guarantee covers the use of ab19390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC/IF ICC/IF: Use at an assay dependent dilution.
IP IP: Use at an assay dependent dilution.
WB WB: 1/1000. Detects a band of approximately 18 kDa (predicted molecular weight: 29 kDa).

Target

  • FunctionEssential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
  • Tissue specificityWidely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
  • Sequence similaritiesBelongs to the APH-1 family.
  • Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
  • Target information above from: UniProt accession Q96BI3 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
      6530402N02Rik antibodyAL138795.3 antibodyAnterior Pharynx Defective 1 antibody
      Anterior pharynx defective 1 homolog A antibodyAPH 1A antibodyAph 1alpha antibodyAPH-1a antibodyAph-1alpha antibodyAph1a antibodyAPH1A_HUMAN antibodyCGI 78 antibodyCGI78 antibodyGamma secretase subunit APH 1A antibodyGamma Secretase Subunit APH1a antibodyGamma-secretase subunit APH-1A antibodyLikely ortholog of C. elegans anterior pharynx defective 1A antibodyPresenilin Stabilization Factor antibodyPresenilin-stabilization factor antibodyPSF antibodyUNQ579/PRO1141 antibody
    see all

Anti-APH1a antibody images



  • Predicted band size : 29 kDa


    Western blot of APH1a in mouse brain and kidney extracts using ab19390.
  • Immunofluorescence staining of APH1a in human KNS42 glioma cells using ab19390.

References for Anti-APH1a antibody (ab19390)

ab19390 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"