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Anti-ARF6 antibody [ARFAG] (ab49931)

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Overview

Product name

Anti-ARF6 antibody [ARFAG]
See all ARF6 products (6) ...

Description

Mouse monoclonal [ARFAG] to ARF6

Tested applications

WB, ELISA, ICCmore details

Cross reactivity

Reacts with

Rat, Cow, Dog, Human

Predicted to work with

Mouse, Chicken, Pig, Xenopus laevis

Immunogen

Synthetic peptide: LTRIRDRNWYVQPSC conjugated to KLH, corresponding to amino acids 141-155 of Human ARF6

LTRIRDRNWY VQPSC

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

MDCK total cell extract

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Clone number

ARFAG

Myeloma

NS1

Isotype

IgG1

Research areas

Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation

Applications

Show applications key

Our Abpromise guarantee covers the use of ab49931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 1 - 2 µg/ml.Detects a band of approximately 18 kDa (predicted molecular weight: 20 kDa).

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    ELISA

     ELISA: Use at an assay d...Read more →

    ELISA: Use at an assay dependent dilution.

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    ICC

     ICC: Use at an assay dep...Read more →

    ICC: Use at an assay dependent dilution.

Target

Relevance

ARF6 (ADP ribosylation factor 6) is a member of the human ARF gene family. These genes encode small guanine nucleotide binding proteins that stimulate the ADP ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking during cellular differentiation and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. ARF6 is a broadly expressed, differentially regulated GTPase that is present in cytoplasm and on both cell surface and intracellular membranes.

Cellular localization

Golgi apparatus. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor.

Alternative names

  • antibody
  • Small GTPase antibody
  • ADP ribosylation factor 6 antibody
  • ADP ribosylation factor protein 6 antibody
  • DKFZp564M0264 antibody
  • Small GTP binding protein antibody
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Database links

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References for Anti-ARF6 antibody [ARFAG] (ab49931)

This product has been referenced in:

  • Eva Ret al. Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells. J Neurosci 30:11654-69 (2010). WB; Rat.Read more (PubMed: 20810886) »
  • Pajcini KVet al. Myoblasts and macrophages share molecular components that contribute to cell-cell fusion. J Cell Biol 180:1005-19 (2008). WB; Mouse.Read more (PubMed: 18332221) »

See all 2 publications for this product

Publishing research using ab49931? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"