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Products:Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
Overview
Product name
Anti-ARF6 antibody [SPM371]
See all ARF6 products (6) ...
Description
Mouse monoclonal [SPM371] to ARF6
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
ARF6 protein.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: BSA, 10mM PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein G purified
Purification notes
Purified from ascites fluid.
Clonality
Monoclonal
Clone number
SPM371
Isotype
IgG1
Light chain type
kappa
Research areas
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
Applications
Show applications key
Our Abpromise guarantee covers the use of ab19871 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 20 kDa.
Target
Relevance
ARF6 (ADP ribosylation factor 6) is a member of the human ARF gene family. These genes encode small guanine nucleotide binding proteins that stimulate the ADP ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking during cellular differentiation and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. ARF6 is a broadly expressed, differentially regulated GTPase that is present in cytoplasm and on both cell surface and intracellular membranes.
Cellular localization
Golgi apparatus. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor.
Alternative names
- antibody
- Small GTPase antibody
- ADP ribosylation factor 6 antibody
see all
Database links
- Entrez Gene: 382 Human
- Omim: 600464 Human
- SwissProt: P62330 Human
- Unigene: 525330 Human
References for Anti-ARF6 antibody [SPM371] (ab19871)
This product has been referenced in:
- Yi Let al. HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking. J Biol Chem 285:30884-905 (2010). WB; Human.Read more (PubMed: 20622010) »
See 1 publication for this product
Publishing research using ab19871? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"