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Western blot - ARHGEF11 antibody (ab56568)
(enlarge)
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Product Name
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ARHGEF11 antibody
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to ARHGEF11
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Immunogen
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Recombinant fragment: RSESLKGREE MKRSRKAENV PRSRSDVDMD AAAEATRLHQ SASSSTSSLS TRSLENPTPP FTPKMGRRSI ESPSLGFCTD TLLPHLLEDD LGQLSDLEPE , corresponding to amino acids 651-750 of Human ARHGEF11
BLAST 'RSESLKGREE MKRSRKAENV PRSRSDVDMD AAAEATRLHQ SASSSTSSLS TRSLENPTPP FTPKMGRRSI ESPSLGFCTD TLLPHLLEDD LGQLSDLEPE ' with  or 
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Reacts with
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Hu
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasm. Membrane. Note: translocated to the membrane upon stimulation.
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Research areas
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Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Ras Family
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Regulators
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Relevance
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ARHGEF11 (Rho guanine nucleotide exchange factor 11) acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. It exhibits transforming ability, associates with and modulates the actin cytoskeleton, regulates neurite outgrowth, and mediates activation of Rho in response to stimulation by activated Galpha12/13. Rat ARHGEF11 interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. ARHGEF11 is also thought to be involved in a pathway known to play a role in both insulin secretion and action.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this ARHGEF11 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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ARHGEF11 antibody images:
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 Western blot - ARHGEF11 antibody (ab56568)
Western blot against tagged recombinant protein immunogen using ab56568 ARHGEF11 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa
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Search PubMed (MEDLINE) for references to ARHGEF11
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ARHGEF11 antibody - more information
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Customer reviews (feedback) regarding ARHGEF11 antibody |
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ARHGEF11 antibody - other tools:
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