Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Regulators
Overview
Product name
Anti-ARHGEF11 antibody
See all ARHGEF11 products (2) ...
Description
Mouse monoclonal to ARHGEF11
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment: RSESLKGREE MKRSRKAENV PRSRSDVDMD AAAEATRLHQ SASSSTSSLS TRSLENPTPP FTPKMGRRSI ESPSLGFCTD TLLPHLLEDD LGQLSDLEPE , corresponding to amino acids 651-750 of Human ARHGEF11
RSESLKGREE MKRSRKAENV PRSRSDVDMD AAAEATRLHQ SASSSTSSLS TRSLENPTPP FTPKMGRRSI ESPSLGFCTD TLLPHLLEDD LGQLSDLEPE
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG1
Light chain type
kappa
Research areas
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Ras Family
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> Small G Proteins >> Regulators
-
Western blot - ARHGEF11 antibody (ab56568)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56568 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Tissue specificity
Ubiquitously expressed.
Sequence similarities
Contains 1 DH (DBL-homology) domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.
Contains 1 RGSL (RGS-like) domain.
Domain
The poly-Pro region is essential for plasma membrane localization upon stimulation.
Cellular localization
Cytoplasm. Membrane. Translocated to the membrane upon stimulation.
Target information above from: UniProt accessionO15085
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ARHGB_HUMAN antibody
- ARHGEF 11 antibody
- ARHGEF11 antibody
see all
Database links
- Entrez Gene: 9826 Human
- Omim: 605708 Human
- SwissProt: O15085 Human
- Unigene: 516954 Human
Anti-ARHGEF11 antibody images:
Western blot - ARHGEF11 antibody (ab56568)
Western blot against tagged recombinant protein immunogen using ab56568 ARHGEF11 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa
References for Anti-ARHGEF11 antibody (ab56568)
ab56568 has not yet been referenced specifically in any publications.
Publishing research using ab56568? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"