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Overview
Product name
Anti-ARIH2 antibody
See all ARIH2 products (5) ...
Description
Mouse monoclonal to ARIH2
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment: KTHGSEYYEC SRYKENPDIV NQSQQAQARE ALKKYLFYFE RWENHNKSLQ LEAQTYQRIH EKIQERVMNN LGTWIDWQYL QNAAKLLAKC , corresponding to amino acids 331-421 of Human ARIH2
KTHGSEYYEC SRYKENPDIV NQSQQAQARE ALKKYLFYFE RWENHNKSLQ LEAQTYQRIH EKIQERVMNN LGTWIDWQYL QNAAKLLAKC
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: Ascites
Concentration
Concentration information loading...
Purity
Ascites
Clonality
Monoclonal
Isotype
IgM
Light chain type
kappa
Research areas
Epigenetics and Nuclear Signaling >> Cell cycle >> Ubiquitin ligases
Epigenetics and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Ubiquitin E2s and E3s >> Other E3 Ligases
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Ubiquitylation
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Western blot - ARIH2 antibody (ab56712)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56712 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.
Tissue specificity
Widely expressed with higher expression in granulocytes.
Pathway
Protein modification; protein ubiquitination.
Sequence similarities
Belongs to the RBR family. Ariadne subfamily.
Contains 1 IBR-type zinc finger.
Contains 2 RING-type zinc fingers.
Domain
RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis.
Post-translational
modifications
Ubiquitinated. Ubiquitination promotes proteasomal degradation.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localization
Nucleus. Cytoplasm.
Target information above from: UniProt accessionO95376
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- HT005 antibody
- Ari-2 antibody
- ARI2 antibody
see all
Database links
- Entrez Gene: 10425 Human
- Omim: 605615 Human
- SwissProt: O95376 Human
- Unigene: 241558 Human
- Unigene: 633601 Human
Anti-ARIH2 antibody images:
Western blot - ARIH2 antibody (ab56712)
Western blot against tagged recombinant protein immunogen using ab56712 ARIH2 antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa
References for Anti-ARIH2 antibody (ab56712)
ab56712 has not yet been referenced specifically in any publications.
Publishing research using ab56712? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"