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Overview

  • Product nameAnti-ARK 1 + 2 antibody
  • Description
    Rabbit polyclonal to ARK 1 + 2
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Xenopus laevis
  • Immunogen

    Synthetic peptide: DRSKENCISG PVKAT FILALKVLFK AQLE conjugated to KLH, corresponding to amino acids 2-16 157-170 of Human ARK 1 + 2.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlHCT-116 cell lysate

Properties

  • FormLiquid
  • Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.05% Sodium Azide
    Constituents: 0.2% Gelatin, PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesProtein G Chromatography
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab22075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 2 - 4 µg/ml. Detects a band of approximately 48 kDa.

Target

  • RelevanceThe Aurora gene, a serine-threonine kinase, orginally discovered in Drosophila, has been found to be responsible for a chromosomal segregation defect. The mammalian homologues of Drosophila Aurora have been termed ARK1 (Aurora-related kinase 1) and ARK2. ARK1 may play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. It may also be involved in microtubule formation and/or stabilization and may play a key role during tumor development and progression. ARK2 may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis.
  • Cellular localizationNuclear
  • Database links
    • Alternative names
        AIK antibodyAIK2 antibodyAIM 1 antibody
        AURA antibodyAurB antibodyAURKB antibodyAurora 1 antibodyAurora A antibodyAurora B antibodyAurora IPL1 like kinase antibodyAurora kinase A antibodyAurora kinase B antibodyBTAK antibodyIPL1 antibodySerine/threonine kinase 12 antibodySerine/threonine kinase 15 antibodySerine/threonine kinase 6 antibodySTK12 antibodySTK15 antibodySTK5 antibodySTK6 antibody
      see all

    Anti-ARK 1 + 2 antibody images

    • Western blot - ARK 1 + 2 antibody (ab22075)
      Western blot - ARK 1 + 2 antibody (ab22075)
      Anti-ARK 1 + 2 antibody (ab22075) at 4 µg/ml + HCT-116 whole cell lysate

      Observed band size : 48 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 18 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-ARK 1 + 2 antibody (ab22075)

    ab22075 has not yet been referenced specifically in any publications.

    Publishing research using ab22075 ? Please let us know so that we can cite the reference in this datasheet

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