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Overview

  • Product nameAnti-ARS2 antibodySee all ARS2 primary antibodies ...
  • Description
    Rabbit polyclonal to ARS2
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to C terminal residues of human ARS2.

Properties

Applications

Our Abpromise guarantee covers the use of ab55822 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 101 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA ELISA: Use at an assay dependent dilution.

Target

  • FunctionActs as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
  • Tissue specificityUbiquitously expressed.
  • Sequence similaritiesBelongs to the ARS2 family.
  • Cellular localizationNucleus > nucleoplasm. Cytoplasm. Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way.

    • Target information above from: UniProt accession Q9BXP5 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
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  • Alternative names
      ARS2 protein antibodyArsenate resistance protein ARS2 antibodyArsenite resistance protein 2 antibody
      Arsenite resistance protein antibodyArsenite-resistance protein 2 antibodyASR2 antibodyMGC126427 antibodySerrate antibodySerrate RNA effector molecule homolog (Arabidopsis) antibodySerrate RNA effector molecule homolog antibodySRRT antibodySRRT_HUMAN antibody
    see all

References for Anti-ARS2 antibody (ab55822)

ab55822 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"