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Product name
Anti-ARTS antibody [ARTS51]
See all ARTS products (5) ...
Description
Mouse monoclonal [ARTS51] to ARTS
Tested applications
ELISA, WB, ICCmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse
Immunogen
Synthetic peptide: NIQDNRVHCCLYFI SPFGHG conjugated to KLH, corresponding to amino acids 247-266 of Human ARTS.
NIQDNRVHCCLYFI SPFGHG
Positive control
Whole extract of transfected 293T (human embryonal kidney) cells expressing ARTS.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Clone number
ARTS51
Isotype
IgG2b
Research areas
Metabolism >> Pathways and Processes >> Metabolism processes >> Apoptosis
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Mitochondrial markers
Cell Biology >> Apoptosis >> Mitochondrial
Cell Biology >> Cell Cycle >> Cell Division >> Cytokinesis
Applications
Show applications key
Our Abpromise guarantee covers the use of ab10440 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
WB: Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 34 kDa.
ICC: Use at an assay dependent dilution.
Target
Function
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.
Tissue specificity
Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets.
Sequence similarities
Belongs to the septin family.
Cellular localization
Cytoplasm. Cytoplasm > cytoskeleton. In platelets, found in areas surrounding alpha-granules and Mitochondrion. Nucleus. While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction.
Target information above from: UniProt accessionO43236
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Apoptosis Related Protein TGFb Signalling antibody
- Apoptosis-related protein in the TGF-beta signaling pathway antibody
- ARTS antibody
see all
Database links
- Entrez Gene: 5414 Human
- Entrez Gene: 18952 Mouse
- Omim: 603696 Human
- SwissProt: O43236 Human
- SwissProt: P28661 Mouse
- Unigene: 287518 Human
- Unigene: 2214 Mouse
References for Anti-ARTS antibody [ARTS51] (ab10440)
ab10440 has not yet been referenced specifically in any publications.
Publishing research using ab10440? Please let us know so that we can cite the reference in this datasheet
![Anti-ARTS antibody [ARTS51] for Immunocytochemistry/ Immunofluorescence in Human (10440)](/ps/datasheet/images/10/ab10440/ARTS-Primary-antibodies-ab10440-10.jpg)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"