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- Proteins and Peptides
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Product name
Anti-ARTS antibody
See all ARTS products (5) ...
Description
Rabbit polyclonal to ARTS
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat
Immunogen
Synthetic peptide: KNIQDNRVHCCLYFISPFGHG conjugated to KLH, corresponding to amino acids 247-266 of Human ARTS (with added N-terminal K).
KNIQDNRVHCCLYFISPFGHG
Positive control
Whole cell extract of HEK 293 cells transfected with ARTS expression plasmid.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Metabolism >> Pathways and Processes >> Metabolism processes >> Apoptosis
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Mitochondrial markers
Cell Biology >> Apoptosis >> Mitochondrial
Cell Biology >> Cell Cycle >> Cell Division >> Cytokinesis
Applications
Show applications key
Our Abpromise guarantee covers the use of ab10441 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/15000. Detects a band of approximately 32 kDa.
Target
Function
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.
Tissue specificity
Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets.
Sequence similarities
Belongs to the septin family.
Cellular localization
Cytoplasm. Cytoplasm > cytoskeleton. In platelets, found in areas surrounding alpha-granules and Mitochondrion. Nucleus. While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction.
Target information above from: UniProt accessionO43236
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Apoptosis Related Protein TGFb Signalling antibody
- Apoptosis-related protein in the TGF-beta signaling pathway antibody
- ARTS antibody
see all
Database links
- Entrez Gene: 5414 Human
- Entrez Gene: 18952 Mouse
- Entrez Gene: 287606 Rat
- Omim: 603696 Human
- SwissProt: O43236 Human
- SwissProt: P28661 Mouse
- SwissProt: A0JN02 Rat
- Unigene: 287518 Human
see all
References for Anti-ARTS antibody (ab10441)
ab10441 has not yet been referenced specifically in any publications.
Publishing research using ab10441? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"