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Products:Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> Other
Overview
Product name
Anti-ASB2 antibody
Description
Rabbit polyclonal to ASB2
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Rat
Immunogen
Synthetic peptides corresponding to amino acids 75-93 and 348-368 of Human ASB2.
tmikegknla epnkegwlp and ntplaperar lyedrr ssaly
Positive control
Human spleen lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Cell cycle >> Ubiquitin ligases
Epigenetics and Nuclear Signaling >> Cell cycle >> Cell Cycle Inhibitors >> Other
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Developmental Families >> Other
Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab13710 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000.Predicted molecular weight: 65 kDa.
Target
Relevance
The ankyrin repeat and SOCS box containing (ASB) protein family is comprised of members which each contain "SOCS boxes" but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are carboxy terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. The gene is induced by all trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
Cellular localization
Cytoplasmic
Alternative names
- Ankyrin repeat and SOCS box 2 containing protein antibody
- Ankyrin repeat and SOCS box containing 2 antibody
- Ankyrin repeat and SOCS box containing protein 2 antibody
- Ankyrin repeat containing protein ASB2 antibody
Database links
- Entrez Gene: 51676 Human
- Omim: 605759 Human
- SwissProt: Q96Q27 Human
- Unigene: 182416 Human
Anti-ASB2 antibody images:
Western blot - Anti-ASB2 antibody (ab13710)
All lanes : Anti-ASB2 antibody (ab13710) at 1/1000 dilution
Lane 1 : Human spleen lysate
Lane 2 : Human lung lysate
Lysates/proteins at 15 µg per lane.
Predicted band size : 65 kDa
Observed band size : 60 kDa (why is the actual band size different from the predicted?)
Western blot - ASB2 antibody (ab13710)
Predicted band size : 65 kDa
Observed band size : 60 kDa (why is the actual band size different from the predicted?)
Additional bands at : 30 kDa. We are unsure as to the identity of these extra bands.
References for Anti-ASB2 antibody (ab13710)
ab13710 has not yet been referenced specifically in any publications.
Publishing research using ab13710? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"