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Anti-ASK1 antibody (ab14379)

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Overview

Product name

Anti-ASK1 antibody
See all ASK1 products (13) ...

Description

Rabbit polyclonal to ASK1

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

Synthetic peptide: EEKDQEIKHLKLKSQP conjugated to KLH, corresponding to amino acids 1276-1291 of ASK1 with C-terminally added Cysteine.

EEKDQEIKHL KLKSQP

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

RIPA lysates from Human SW1353 cell.

General notes

Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide before the addition of glycerol to 30%.

Properties

Form

Liquid

Storage instructions

Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: 30% Glycerol, 0.15M Sodium chloride, 0.1mM Tris glycine

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cardiovascular >> Heart >> Hypertrophy >> Other
Cardiovascular >> Heart >> Apoptosis
Cell Biology >> Apoptosis >> Intracellular >> Kinases

Applications

Show applications key

Our Abpromise guarantee covers the use of ab14379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 2 - 4 µg/ml.Predicted molecular weight: 155 kDa.

Target

Function

Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.

Tissue specificity

Abundantly expressed in heart and pancreas.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.

Post-translational
modifications

Dephosphorylated and activated by PGAM5.

Target information above from: UniProt accessionQ99683 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Apoptosis signal regulating kinase 1 antibody
  • Apoptosis signal-regulating kinase 1 antibody
  • ASK 1 antibody
  • ASK-1 antibody
  • ASK1 antibody
  • M3K5_HUMAN antibody
  • MAP/ERK kinase kinase 5 antibody
  • MAP3K5 antibody
  • MAPK/ERK kinase kinase 5 antibody
  • MAPKKK5 antibody
  • MEK kinase 5 antibody
  • MEKK 5 antibody
  • MEKK5 antibody
  • Mitogen activated protein kinase kinase kinase 5 antibody
  • Mitogen-activated protein kinase kinase kinase 5 antibody
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Database links

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References for Anti-ASK1 antibody (ab14379)

This product has been referenced in:

  • Ebrahimian Tet al. Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause. Am J Physiol Heart Circ Physiol 295:H1481-8 (2008). WB; Mouse.Read more (PubMed: 18676690) »

See 1 publication for this product

Publishing research using ab14379? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"