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Anti-ASK1 antibody (ab2004)

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Overview

Product name

Anti-ASK1 antibody
See all ASK1 products (13) ...

Description

Rabbit polyclonal to ASK1

Tested applications

IP, WB, ICC/IFmore details

Cross reactivity

Reacts with

Human

Immunogen

Peptide sequence corresponding to amino acids 1356 to 1375 ofhuman ASK1 (1). This sequence is different from that of mouse by last two amino acids (3).

Positive control

SW1353, A431 and K-562 whole cell lysates

General notes

Apoptosis Signal-regulation Kinase

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS with 0.02% sodium azide

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

  • Western blot - ASK1 antibody (ab2004)Western blot - ASK1 antibody (ab2004) image (enlarge)

  • Immunocytochemistry/ Immunofluorescence - ASK1 antibody (ab2004)Immunocytochemistry/ Immunofluorescence - ASK1 antibody (ab2004) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab2004 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.

Tissue specificity

Abundantly expressed in heart and pancreas.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.

Post-translational
modifications

Dephosphorylated and activated by PGAM5.

Target information above from: UniProt accessionQ99683 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Apoptosis signal regulating kinase 1 antibody
  • Apoptosis signal-regulating kinase 1 antibody
  • ASK 1 antibody
  • ASK-1 antibody
  • ASK1 antibody
  • M3K5_HUMAN antibody
  • MAP/ERK kinase kinase 5 antibody
  • MAP3K5 antibody
  • MAPK/ERK kinase kinase 5 antibody
  • MAPKKK5 antibody
  • MEK kinase 5 antibody
  • MEKK 5 antibody
  • MEKK5 antibody
  • Mitogen activated protein kinase kinase kinase 5 antibody
  • Mitogen-activated protein kinase kinase kinase 5 antibody
see all

Anti-ASK1 antibody images:

  Western blot - ASK1 antibody (ab2004)

Western blot - ASK1 antibody (ab2004)

Anti-ASK1 antibody (ab2004) at 1/500 dilution + SW1351 whole cell lysate

Predicted band size : 155 kDa

  Immunocytochemistry/ Immunofluorescence - ASK1 antibody (ab2004)

Immunocytochemistry/ Immunofluorescence - ASK1 antibody (ab2004)

ab2004 at 10µg/ml staining ASK1 in A431 cells by ICC/IF

References for Anti-ASK1 antibody (ab2004)

This product has been referenced in:

  • Filomeni Get al. Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP kinase pathway. FASEB J 17:64-6 (2003). WB, IP; Human.Read more (PubMed: 12424221) »

See 1 publication for this product

Publishing research using ab2004? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"