The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
FunctionComponent of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.
Tissue specificityAbundantly expressed in heart and pancreas.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain.
Post-translational modificationsDephosphorylated and activated by PGAM5.
ab39650, at 1/50 dilution, staining ASK1 in Human breast carcinoma tissue by Immunohistochemistry, Paraffin embedded tissue. Left: sample not treated with peptide. Right: sample treated with synthetic peptide.
References for Anti-ASK1 antibody (ab39650)
has not yet been referenced specifically in any publications.
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