Anti-ASK1 antibody (ab39650)

Overview

• Product nameAnti-ASK1 antibodySee all ASK1 primary antibodies ...
• Description
  Rabbit polyclonal to ASK1
• Specificityab39650 detects endogenous levels of total ASK1 protein.
• Tested applicationsELISA, IHC-P more details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  Synthetic peptide (non-phosphorylated) derived from Human ASK1 around the phosphorylation site of Serine 966.

• Positive controlHuman breast carcinoma.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cardiovascular
  • Heart
  • Hypertrophy
  • Other

  • Cardiovascular
  • Heart
  • Apoptosis

  • Cell Biology
  • Apoptosis
  • Intracellular
  • Kinases

Applications

Target

• FunctionComponent of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.
• Tissue specificityAbundantly expressed in heart and pancreas.
• Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  Contains 1 protein kinase domain.
• Post-translational
  modificationsDephosphorylated and activated by PGAM5.

Target information above from: UniProt accession Q99683 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 4217 Human
  • Entrez Gene: 26408 Mouse
  • Omim: 602448 Human
  • SwissProt: Q99683 Human
  • SwissProt: O35099 Mouse
  • Unigene: 186486 Human
  • Unigene: 6595 Mouse

• Alternative names
  Apoptosis signal regulating kinase 1 antibodyApoptosis signal-regulating kinase 1 antibodyASK 1 antibody

  ASK-1 antibodyASK1 antibodyM3K5 antibodyM3K5_HUMAN antibodyMAP/ERK kinase kinase 5 antibodyMAP3K5 antibodyMAPK/ERK kinase kinase 5 antibodyMAPKKK5 antibodyMEK kinase 5 antibodyMEKK 5 antibodyMEKK5 antibodyMitogen activated protein kinase kinase kinase 5 antibodyMitogen-activated protein kinase kinase kinase 5 antibody

  see all

Anti-ASK1 antibody images

• 

  Immunohistochemistry (Paraffin-embedded sections) - ASK1 antibody (ab39650)
  ab39650, at 1/50 dilution, staining ASK1 in Human breast carcinoma tissue by Immunohistochemistry, Paraffin embedded tissue. Left: sample not treated with peptide. Right: sample treated with synthetic peptide.