Anti-ASK1 (phospho S966) antibody (ab39402)

Overview

• Product nameAnti-ASK1 (phospho S966) antibodySee all ASK1 primary antibodies ...
• Description
  Rabbit polyclonal to ASK1 (phospho S966)
• Specificityab39402 detects endogenous levels of ASK1 only when phosphorylated at Serine 966.
• Tested applicationsELISA, IHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse
• Immunogen

  Synthetic phosphopeptide: SIS_pLP, derived from Human ASK1 around the phosphorylation site of Serine 966

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab39402 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non phosphopeptide was removed by chromatography using non phosphopeptide corresponding to the phosphorylation site.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cardiovascular
  • Heart
  • Hypertrophy
  • Other

  • Cardiovascular
  • Heart
  • Apoptosis

  • Cell Biology
  • Apoptosis
  • Intracellular
  • Kinases

Applications

Target

• FunctionComponent of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.
• Tissue specificityAbundantly expressed in heart and pancreas.
• Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  Contains 1 protein kinase domain.
• Post-translational
  modificationsDephosphorylated and activated by PGAM5.

Target information above from: UniProt accession Q99683 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 4217 Human
  • Entrez Gene: 26408 Mouse
  • Omim: 602448 Human
  • SwissProt: Q99683 Human
  • SwissProt: O35099 Mouse
  • Unigene: 186486 Human
  • Unigene: 6595 Mouse

• Alternative names
  Apoptosis signal regulating kinase 1 antibodyApoptosis signal-regulating kinase 1 antibodyASK 1 antibody

  ASK-1 antibodyASK1 antibodyM3K5 antibodyM3K5_HUMAN antibodyMAP/ERK kinase kinase 5 antibodyMAP3K5 antibodyMAPK/ERK kinase kinase 5 antibodyMAPKKK5 antibodyMEK kinase 5 antibodyMEKK 5 antibodyMEKK5 antibodyMitogen activated protein kinase kinase kinase 5 antibodyMitogen-activated protein kinase kinase kinase 5 antibody

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Anti-ASK1 (phospho S966) antibody images

• 

  Immunohistochemistry (Paraffin-embedded sections) - ASK1 (phospho S996) antibody (ab39402)
  ab39402, at a 1/100 dilution, staining human ASK1 in breast carcinoma tissue by Immunohistochemistry, Paraffin embedded tissue.
• 

  Immunohistochemistry (Paraffin-embedded sections) - ASK1 (phospho S996) antibody (ab39402)
  ab39402, at a 1/100 dilution, staining human ASK1 in breast carcinoma tissue (treated with synthesized phosphopeptide) by Immunohistochemistry, Paraffin embedded tissue.