Overview

  • Product nameAnti-ASPA antibodySee all ASPA primary antibodies ...
  • Description
    Mouse monoclonal to ASPA
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment: MTSCHIAEEH IQKVAIFGGT HGNELTGVFL VKHWLENGAE IQRTGLEVKP FITNPRAVKK CTRYIDCDLN RIFDLENLGK KMSEDLPYEV RRAQEINHLF , corresponding to amino acids 1-101 of Human ASPA

Properties

Applications

Our Abpromise guarantee covers the use of ab54849 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCatalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
    • Tissue specificityBrain white matter, skeletal muscle, kidney, adrenal glands, lung and liver.
    • Involvement in diseaseDefects in ASPA are the cause of Canavan disease (CAND) [MIM:271900]; also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average.
    • Sequence similaritiesBelongs to the AspA/AstE family. Aspartoacylase subfamily.
    • Cellular localizationCytoplasm. Nucleus.
    • Target information above from: UniProt accession P45381 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • ACY 2 antibody
      • ACY-2 antibody
      • ACY2 antibody
      • ACY2_HUMAN antibody
      • Aminoacylase 2 antibody
      • Aminoacylase-2 antibody
      • Aminoacylase2 antibody
      • ASP antibody
      • ASPA antibody
      • Aspartoacylase (aminoacylase 2, Canavan disease) antibody
      • Aspartoacylase (Canavan disease) antibody
      • Aspartoacylase antibody
      • NUR 7 antibody
      • NUR7 antibody
      • OTTMUSP00000006437 antibody
      • RP23-213I10.1 antibody
      • Small lethargic antibody
      see all

    Anti-ASPA antibody images

    • Western blot against tagged recombinant protein immunogen using ab54849 ASPA antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    References for Anti-ASPA antibody (ab54849)

    ab54849 has not yet been referenced specifically in any publications.

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