Anti-ATF6 antibody (ab22280)

Overview

• Product nameAnti-ATF6 antibodySee all ATF6 primary antibodies ...
• Description
  Rabbit polyclonal to ATF6
• Tested applicationsELISA more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Synthetic peptide: EVERTKSRRMTNNQQKTRI, corresponding to amino acids 491-509 of Human ATF6.

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.025% Sodium Azide
  Constituents: 50% Glycerol, Whole serum
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • HLH / Leucine Zipper
  • Leucine Zipper

Applications

Target

• FunctionTranscription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.
• Tissue specificityUbiquitous.
• Sequence similaritiesBelongs to the bZIP family. ATF subfamily.
  Contains 1 bZIP domain.
• DomainThe basic domain functions as a nuclear localization signal.
  The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.
• Post-translational
  modificationsDuring unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases.
  N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR).
  Phosphorylated in vitro by MAPK14/P38MAPK.
• Cellular localizationEndoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Target information above from: UniProt accession P18850 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 22926 Human
  • Entrez Gene: 226641 Mouse
  • Entrez Gene: 304962 Rat
  • Omim: 605537 Human
  • SwissProt: P18850 Human
  • Unigene: 492740 Human

• Alternative names
  Activating transcription factor 6 alpha antibodyActivating transcription factor 6 antibodyATF 6 antibody

  ATF6 alpha antibodyATF6 antibodyATF6-alpha antibodyATF6A antibodyATF6A_HUMAN antibodycAMP dependent transcription factor ATF 6 alpha antibodycAMP-dependent transcription factor ATF-6 alpha antibodyCyclic AMP dependent transcription factor ATF 6 alpha antibodyDKFZp686P2194 antibodyESTM49 antibodyFLJ21663 antibodyProcessed cyclic AMP dependent transcription factor ATF 6 alpha antibodyProcessed cyclic AMP-dependent transcription factor ATF-6 alpha antibody

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