Anti-ATF6 beta antibody (ab26085)

Overview

• Product nameAnti-ATF6 beta antibodySee all ATF6 beta primary antibodies ...
• Description
  Rabbit polyclonal to ATF6 beta
• Tested applicationsELISA, WB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Cow, Pig
• Immunogen

  Synthetic peptide: MAELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR, corresponding to a region within N terminal amino acids 1-50 of Rabbit ATF6 beta

  Run BLAST with Run BLAST with
• Positive controlHepG2 cell lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None.
  Constituents: 2% Sucrose, PBS.
• Concentration information loading...
• PurityProtein A purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

Applications

Target

• FunctionTranscriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.
• Tissue specificityUbiquitous.
• Sequence similaritiesBelongs to the bZIP family. ATF subfamily.
  Contains 1 bZIP domain.
• DomainThe basic domain functions as a nuclear localization signal.
  The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.
• Post-translational
  modificationsN-glycosylated.
  During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.
• Cellular localizationEndoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Target information above from: UniProt accession Q99941 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 1388 Human
  • Entrez Gene: 12915 Mouse
  • Entrez Gene: 406169 Rat
  • Omim: 600984 Human
  • SwissProt: Q5SSW7 Human
  • SwissProt: Q99941 Human
  • SwissProt: O35451 Mouse
  • SwissProt: Q6MG80 Rat

  • SwissProt: Q4G097 Rat
  • Unigene: 42853 Human
  • Unigene: 4068 Mouse
  • Unigene: 18179 Rat

  see all

• Alternative names
  Activating transcription factor 6 beta antibodyActivating transcription factor 6 beta antibodyATF 6 beta antibody

  ATF6-beta antibodyATF6B antibodyATF6B_HUMAN antibodyATF6beta antibodycAMP response element binding protein related protein antibodycAMP response element-binding protein-related protein antibodycAMP responsive element binding protein like 1 antibodycAMP-dependent transcription factor ATF-6 beta antibodycAMP-responsive element-binding protein-like 1 antibodyCREB L1 antibodyCreb related protein antibodyCREB RP antibodyCreb-rp antibodyCREBL 1 antibodyCREBL1 antibodyCrebrp antibodyCyclic AMP dependent transcription factor ATF 6 beta antibodyCyclic AMP dependent transcription factor ATF6 beta antibodyFLJ10066 antibodyG13 antibodyG13 protein antibodyG13 protein antibodyOTTHUMP00000029432 antibodyOTTHUMP00000029433 antibodyProcessed cyclic AMP-dependent transcription factor ATF-6 beta antibodyProtein G13 antibody

  see all

Anti-ATF6 beta antibody images

• 

  Western blot - ATF6 beta antibody (ab26085)
  Anti-ATF6 beta antibody (ab26085) at 2.5 µg/ml + HepG2 cell lysate (10ug).
  
  Secondary
  HRP conjugated anti Rabbit IgG at 1/50000 dilution
  
  Predicted band size : 77 kDa
  Observed band size : 77 kDa