ATP citrate lyase antibody [EP704Y] (ab40793)

Product Name 

ATP citrate lyase antibody [EP704Y]

Product type 

Primary antibodies

Description 

Rabbit monoclonal [EP704Y] to ATP citrate lyase

Immunogen 

Synthetic peptide corresponding to residues in the C-term of human ATP citrate lyase.

Reacts with 
(species key)

Hu, Ms, Rat

Specificity 

ab40793 recognises ATP citrate lyase (ACL).

Tested applications 
(see key)

Flow Cyt, IP, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
Flow Cyt: 1/30.
IP: 1/50.
WB: 1/1000 - 1/5000. Detects a band of approximately 125 kDa (predicted molecular weight: 122 kDa).


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cytoplasmic

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Signal Transduction >> Metabolism >> Lipid metabolism
Signal Transduction >> Metabolism >> Energy Metabolism

Relevance 

ATP citrate lyase (ACL) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of four identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. One of these products, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. NDPK has been found to phosphorylate ACL and insulin to increase phosphorylation of ACL.

Database links 

Raised in 

Rabbit

Clonality 

Monoclonal

Clone number 

EP704Y

Isotype 

IgG

Purity 

IgG fraction

Storage buffer 

Preservative: 0.01% Sodium Azide
Constituents: 40% Glycerol, 0.05% BSA, 0.15M Sodium chloride, 50mM Tris glycine, pH 7.4

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes 

Produced under U.S. Patent No. 5,675,063.

See below for ATP citrate lyase antibody [EP704Y] images, references, products related to ab40793 and other tools.

ATP citrate lyase antibody [EP704Y] images:

References for ATP citrate lyase antibody [EP704Y] (ab40793)

  This product has been used in: (two most recent references)

Schjoldager KT et al. Cellular cross-talk in the small intestinal mucosa: postnatal lymphocytic immigration elicits a specific epithelial transcriptional response. Am J Physiol Gastrointest Liver Physiol : (2008). PubMed: 18388184

Mailloux R et al. Aluminum-induced mitochondrial dysfunction leads to lipid accumulation in human hepatocytes: a link to obesity. Cell Physiol Biochem 20:627-38 (2007). WB; Human. PubMed: 17762189
If you publish research using ab40793 please let us know so that we can cite the reference on this datasheet.

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