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Anti-ATP citrate lyase (phospho S455) antibody [EP828Y] (ab46796)

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Overview

Product name

Anti-ATP citrate lyase (phospho S455) antibody [EP828Y]
See all ATP citrate lyase products (7) ...

Description

Rabbit monoclonal [EP828Y] to ATP citrate lyase (phospho S455)

Tested applications

WB, IPmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic peptide corresponding to residues of ATP citrate lyase (Human).

Positive control

Insulin treated 3T3 cell lysate.

General notes

Produced under U.S. Patent No. 5,675,063.

Properties

Form

Liquid

Storage instructions

Store at -20°C. Stable for 12 months at -20°C

Storage buffer

PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

EP828Y

Isotype

IgG

Research areas

Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Energy transfer pathways >> Integration of energy
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Energy transfer pathways >> Energy Metabolism
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Signal Transduction >> Metabolism >> Lipid metabolism
Signal Transduction >> Metabolism >> Energy Metabolism

  • Western blot - ATP citrate lyase (phospho S455) antibody [EP828Y] (ab46796)Western blot - ATP citrate lyase (phospho S455) antibody [EP828Y] (ab46796) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab46796 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

Is unsuitable for ,Flow Cyt,ICC or IHC-P.

Target

Function

ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Sequence similarities

In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.

Post-translational
modifications

ISGylated.

Cellular localization

Cytoplasm.

Target information above from: UniProt accessionP53396 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ACL antibody
  • Acly antibody
  • ACLY_HUMAN antibody
  • ATP citrate (pro-S) lyase antibody
  • ATP citrate lyase antibody
  • ATP citrate synthase antibody
  • ATP-citrate (pro-S-)-lyase antibody
  • ATP-citrate synthase antibody
  • ATPcitrate synthase antibody
  • ATPCL antibody
  • Citrate cleavage enzyme antibody
  • CLATP antibody
  • EC 2.3.3.8 antibody
  • OTTHUMP00000164773 antibody
see all

Database links

see all

Anti-ATP citrate lyase (phospho S455) antibody [EP828Y] images:

  Western blot - ATP citrate lyase (phospho S455) antibody [EP828Y] (ab46796)

Western blot - ATP citrate lyase (phospho S455) antibody [EP828Y] (ab46796)

All lanes : Anti-ATP citrate lyase (phospho S455) antibody [EP828Y] (ab46796) at 1/5000 dilution

Lane 1 : Untreated 3T3 cell lysates
Lane 2 : Insulin treated 3T3 cell lysates

Lysates/proteins at 10 µg per lane.

Secondary
Goat anti-rabbit HRP at 1/2000 dilution

Observed band size : 125 kDa (why is the actual band size different from the predicted?)

References for Anti-ATP citrate lyase (phospho S455) antibody [EP828Y] (ab46796)

ab46796 has not yet been referenced specifically in any publications.

Publishing research using ab46796? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"