Anti-ATP citrate lyase (phospho S455) antibody (ab59297)

Overview

  • Product nameAnti-ATP citrate lyase (phospho S455) antibodySee all ATP citrate lyase primary antibodies ...
  • Description
    Rabbit polyclonal to ATP citrate lyase (phospho S455)
  • SpecificityDetects endogenous levels of ATP Citrate Lyase only when phosphorylated at serine 455.
  • Tested applicationsELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from human ATP Citrate Lyase around the phosphorylation site of serine 455 (T-A-SP-F-S).

  • Positive control
    • Human colon carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab59297 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/5000.
IHC-P Use at an assay dependent dilution.

Target

  • FunctionATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
  • Sequence similaritiesIn the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
    In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
    Contains 1 ATP-grasp domain.
  • Post-translational
    modifications
    ISGylated.
    Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2.
    Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACL antibody
    • Acly antibody
    • ACLY_HUMAN antibody
    • ATP citrate (pro-S) lyase antibody
    • ATP citrate lyase antibody
    • ATP citrate synthase antibody
    • ATP-citrate (pro-S-)-lyase antibody
    • ATP-citrate synthase antibody
    • ATPcitrate synthase antibody
    • ATPCL antibody
    • Citrate cleavage enzyme antibody
    • CLATP antibody
    • EC 2.3.3.8 antibody
    • OTTHUMP00000164773 antibody
    see all

Anti-ATP citrate lyase (phospho S455) antibody images

  • Ab59297 at 1/50 dilution staining human colon carcinoma without (left) and with (right) immunizing peptide; paraffin embedded.

References for Anti-ATP citrate lyase (phospho S455) antibody (ab59297)

ab59297 has not yet been referenced specifically in any publications.

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