Anti-ATP citrate lyase (phospho S455) antibody (ab59297)

Overview

• Product nameAnti-ATP citrate lyase (phospho S455) antibodySee all ATP citrate lyase primary antibodies ...
• Description
  Rabbit polyclonal to ATP citrate lyase (phospho S455)
• SpecificityDetects endogenous levels of ATP Citrate Lyase only when phosphorylated at serine 455.
• Tested applicationsELISA, IHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Synthetic phosphopeptide derived from human ATP Citrate Lyase around the phosphorylation site of serine 455 (T-A-S^P-F-S).

• Positive controlHuman colon carcinoma tissue

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS (without Mg²⁺ and Ca²⁺), 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Integration of energy

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Integration of energy metabolism

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Signal Transduction
  • Metabolism
  • Energy Metabolism

Applications

Target

• FunctionATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
• Sequence similaritiesIn the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
  In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
• Post-translational
  modificationsISGylated.
• Cellular localizationCytoplasm.

Target information above from: UniProt accession P53396 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 47 Human
  • Entrez Gene: 104112 Mouse
  • Entrez Gene: 24159 Rat
  • Omim: 108728 Human
  • SwissProt: P53396 Human
  • SwissProt: Q91V92 Mouse
  • SwissProt: P16638 Rat
  • Unigene: 387567 Human

  • Unigene: 282039 Mouse
  • Unigene: 29771 Rat

  see all

• Alternative names
  ACL antibodyAcly antibodyACLY_HUMAN antibody

  ATP citrate (pro-S) lyase antibodyATP citrate lyase antibodyATP citrate synthase antibodyATP-citrate (pro-S-)-lyase antibodyATP-citrate synthase antibodyATPcitrate synthase antibodyATPCL antibodyCitrate cleavage enzyme antibodyCLATP antibodyEC 2.3.3.8 antibodyOTTHUMP00000164773 antibody

  see all

Anti-ATP citrate lyase (phospho S455) antibody images

• 

  Immunohistochemistry (Paraffin-embedded sections) - ATP citrate lyase (phospho S455) antibody (ab59297)
  Ab59297 at 1/50 dilution staining human colon carcinoma without (left) and with (right) immunizing peptide; paraffin embedded.