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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> ATM / ATR
Overview
Product name
Anti-ATRIP antibody
See all ATRIP products (5) ...
Description
Rabbit polyclonal to ATRIP
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
This information is considered to be commercially sensitive.
Epitope
The epitope recognized by ab17962 maps to a region between residues 500 and 550 of human ATRIP.
Positive control
HeLa whole cell lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
Purified using an epitope specific to ATRIP immobilized on solid support.
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> Other
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> ATM / ATR
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- ATRIP antibody (ab17962)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab17962 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/5000 - 1/15000.Detects a band of approximately 95 kDa (predicted molecular weight: 86.8 kDa).
Target
Relevance
The product of the ATRIP gene is an essential component of the DNA damage checkpoint, and binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
Cellular localization
Nuclear
Alternative names
- 3' Repair Exonuclease 1 antibody
- 3'-5' exonuclease TREX1 antibody
- AGS 1 antibody
see all
Database links
- Entrez Gene: 84126 Human
- Omim: 606605 Human
- SwissProt: Q8WXE1 Human
- Unigene: 694840 Human
Anti-ATRIP antibody images:
- ATRIP antibody (ab17962)
Detection of Human ATRIP using ab17962 by Western Blot (2 x left images) and Immunoprecipitation (right image).
Samples: Whole cell lysate (100
Antibodies: Affinity purified rabbit anti-ATRIP antibody (ab17962) used at 1/500 and 1/15000 dilution for WB and 3
ATRIP was also immunoprecipitated using a control antibody generated to recombinant human ATRIP:
Right image - lane 1 ab17962; lane 2 control antibody; lane 3 normal IgG.
Immunoprecipitated ATRIP was detected using the antibody to the recombinant protein. Detection: Chemiluminescence with exposure times of 5 minutes (2 x left) and 45 seconds (right image).
References for Anti-ATRIP antibody (ab17962)
ab17962 has not yet been referenced specifically in any publications.
Publishing research using ab17962? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"