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Western blot - ATRX antibody (ab54794)
(enlarge)
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Product Name
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ATRX antibody
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See all ATRX antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to ATRX
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Immunogen
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Recombinant fragment: FNLGALSAMS NQQLEDLINQ GREKVVEATN SVTAVRIQPL EDIISAVWKE NMNLSEAQVQ ALALSRQASQ ELDVKRREAI YNDVLTKQQM LISCVQRILM , corresponding to amino acids 2311-2411 of Human ATRX
BLAST 'FNLGALSAMS NQQLEDLINQ GREKVVEATN SVTAVRIQPL EDIISAVWKE NMNLSEAQVQ ALALSRQASQ ELDVKRREAI YNDVLTKQQM LISCVQRILM ' with  or 
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Reacts with
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RecFrag
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Predicted to react
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Hu
(Due to sequence homology)
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Tested applications
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> Chromatin Remodeling >> Swi / Snf
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Relevance
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ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of ATRX gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. ATRX is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this ATRX antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for ATRX antibody images, references, products related to ab54794 and other tools.
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ATRX antibody images:
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 Western blot - ATRX antibody (ab54794)
Western blot against tagged recombinant protein immunogen using ab54794 ATRX antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
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Search PubMed (MEDLINE) for references to ATRX
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ATRX antibody - more information
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Customer reviews (feedback) regarding ATRX antibody |
Customer FAQs regarding ATRX antibody |
Protocols for ATRX antibody |
Price and availability of products related to ATRX antibody |
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ATRX antibody - related products:
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ATRX antibody - other tools:
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Contact Abcam with a Technical Enquiry about ATRX antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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