Anti-ATRX antibody (ab84462)

Overview

• Product nameAnti-ATRX antibodySee all ATRX primary antibodies ...
• Description
  Rabbit polyclonal to ATRX
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide, corresponding to a region between C terminal amino acids 2442-2492 of Human ATRX (NP_000480.2).

• Positive controlhuman Breast Carcinoma, Linitis Plastica Stomach Cancer, Ovarian Carcinoma, Prostate Carcinoma, Skin Basal Cell Carcinoma, Stomach Adenocarcinoma tissue.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: 0.1% BSA, Tris buffered saline
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesAntibody was affinity purified using an epitope specific to ATRX immobilized on solid support.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Chromatin Remodeling
  • Swi / Snf

Applications

Target

• FunctionCould be a global transcriptional regulator. Modifies gene expression by affecting chromatin. May be involved in brain development and facial morphogenesis.
• Tissue specificityUbiquitous.
• Involvement in diseaseDefects in ATRX are the cause of alpha-thalassemia mental retardation syndrome X-linked non-deletion type (ATRX) [MIM:301040]. ATR-X is an X-linked disorder comprising severe psychomotor retardation, facial dysmorphism, urogenital abnormalities, and alpha-thalassemia. An essential phenotypic trait are hemoglobin H erythrocyte inclusions.
  Defects in ATRX are the cause of mental retardation syndromic X-linked with hypotonic facies syndrome type 1 (MRXSHF1) [MIM:309580]; also called Carpenter-Waziri syndrome (CWS), Juberg-Marsidi syndrome (JMS), Smith-Fineman-Myers syndrome type 1 (SFM1). Clinical features include severe mental retardation, dysmorphic facies, and a highly skewed X-inactivation pattern in carrier women. Other more variable features include hypogonadism, deafness, renal anomalies, and mild skeletal defects.
  Defects in ATRX are a cause of alpha-thalassemia myelodysplasia syndrome (ATMDS) [MIM:300448]. In this disorder, alpha-thalassemia occurs as an acquired abnormality in association with a multilineage myelodysplasia.
• Sequence similaritiesBelongs to the SNF2/RAD54 helicase family.
  Contains 1 ADD domain.
  Contains 1 GATA-type zinc finger.
  Contains 1 helicase ATP-binding domain.
  Contains 1 helicase C-terminal domain.
  Contains 1 PHD-type zinc finger.
• DomainContains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
• Post-translational
  modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
• Cellular localizationNucleus. Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with HP1.

Target information above from: UniProt accession P46100 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 546 Human
  • Omim: 301040 Human
  • SwissProt: P46100 Human
  • Unigene: 533526 Human
  • Unigene: 653797 Human

• Alternative names
  Alpha thalassemia/mental retardation syndrome X linked homolog antibodyATP dependent helicase ATRX antibodyATP-dependent helicase ATRX antibody

  ATR2 antibodyAtrx antibodyATRX_HUMAN antibodyDNA dependent ATPase and helicase antibodyHelicase 2, X linked antibodyMGC2094 antibodyMRXHF1 antibodyRAD54 antibodyRAD54L antibodySFM1 antibodySHS antibodyTranscriptional regulator ATRX antibodyX linked helicase II antibodyX linked nuclear protein antibodyX-linked helicase II antibodyX-linked nuclear protein antibodyXH2 antibodyXNP antibodyZnf HX antibodyZnf-HX antibody

  see all

Anti-ATRX antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ATRX antibody (ab84462)
  ab84462, at 1/250 dilution, staining ATRX in formalin-fixed, paraffin-embedded human breast carcinoma by Immunohistochemistry, using DAB detectioN.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ATRX antibody (ab84462)
  ab84462, at 1/250 dilution, staining ATRX in formalin-fixed, paraffin-embedded human basal cell carcinoma by Immunohistochemistry, using DAB detection.