Anti-ATRX antibody (ab84462)
- Product nameAnti-ATRX antibodySee all ATRX primary antibodies ...
- DescriptionRabbit polyclonal to ATRX
- Tested applicationsIHC-P more details
- Species reactivityReacts with: Human
Synthetic peptide, corresponding to a region between C terminal amino acids 2442-2492 of Human ATRX (NP_000480.2).
- Positive controlhuman Breast Carcinoma, Linitis Plastica Stomach Cancer, Ovarian Carcinoma, Prostate Carcinoma, Skin Basal Cell Carcinoma, Stomach Adenocarcinoma tissue.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPreservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
- Concentration information loading...
- PurityImmunogen affinity purified
- Purification notesAntibody was affinity purified using an epitope specific to ATRX immobilized on solid support.
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab84462 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionCould be a global transcriptional regulator. Modifies gene expression by affecting chromatin. May be involved in brain development and facial morphogenesis.
- Tissue specificityUbiquitous.
- Involvement in diseaseDefects in ATRX are the cause of alpha-thalassemia mental retardation syndrome X-linked non-deletion type (ATRX) [MIM:301040]. ATR-X is an X-linked disorder comprising severe psychomotor retardation, facial dysmorphism, urogenital abnormalities, and alpha-thalassemia. An essential phenotypic trait are hemoglobin H erythrocyte inclusions.
Defects in ATRX are the cause of mental retardation syndromic X-linked with hypotonic facies syndrome type 1 (MRXSHF1) [MIM:309580]; also called Carpenter-Waziri syndrome (CWS), Juberg-Marsidi syndrome (JMS), Smith-Fineman-Myers syndrome type 1 (SFM1). Clinical features include severe mental retardation, dysmorphic facies, and a highly skewed X-inactivation pattern in carrier women. Other more variable features include hypogonadism, deafness, renal anomalies, and mild skeletal defects.
Defects in ATRX are a cause of alpha-thalassemia myelodysplasia syndrome (ATMDS) [MIM:300448]. In this disorder, alpha-thalassemia occurs as an acquired abnormality in association with a multilineage myelodysplasia.
- Sequence similaritiesBelongs to the SNF2/RAD54 helicase family.
Contains 1 ADD domain.
Contains 1 GATA-type zinc finger.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Contains 1 PHD-type zinc finger.
- DomainContains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
- Cellular localizationNucleus. Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with HP1.
- Alpha thalassemia/mental retardation syndrome X linked homolog antibodyATP dependent helicase ATRX antibodyATP-dependent helicase ATRX antibody
- ATR2 antibodyAtrx antibodyATRX_HUMAN antibodyDNA dependent ATPase and helicase antibodyHelicase 2, X linked antibodyMGC2094 antibodyMRXHF1 antibodyRAD54 antibodyRAD54L antibodySFM1 antibodySHS antibodyTranscriptional regulator ATRX antibodyX linked helicase II antibodyX linked nuclear protein antibodyX-linked helicase II antibodyX-linked nuclear protein antibodyXH2 antibodyXNP antibodyZnf HX antibodyZnf-HX antibody
Anti-ATRX antibody images
ab84462, at 1/250 dilution, staining ATRX in formalin-fixed, paraffin-embedded human breast carcinoma by Immunohistochemistry, using DAB detectioN.
ab84462, at 1/250 dilution, staining ATRX in formalin-fixed, paraffin-embedded human basal cell carcinoma by Immunohistochemistry, using DAB detection.
References for Anti-ATRX antibody (ab84462)
ab84462 has not yet been referenced specifically in any publications.