You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameAbhd5 peptideSee all Abhd5 proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 150 - 250 of Human Abhd5.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab73551 - Abhd5 antibody.
  • Protein length349 amino acids

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab73551.

    • Protein info

    • Alternative names
        1-acylglycerol-3-phosphate O-acyltransferase ABHD5ABHD5ABHD5_HUMAN
        Abhydrolase domain containing 5Abhydrolase domain containing protein 5Abhydrolase domain-containing protein 5CDSCGI 58CGI58CGI58 proteinIECN2Lipid droplet-binding protein CGI-58MGC8731NCIE2
      see all
  • FunctionLysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation.
  • Tissue specificityWidely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level).
  • Involvement in diseaseDefects in ABHD5 are the cause of Chanarin-Dorfman syndrome (CDS) [MIM:275630]; also called triglyceride storage disease with impaired long-chain fatty acid oxidation or neutral lipid storage disease with ichthyosis. CDS is an autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Clinical characteristics are congenital generalized ichthyosis, vacuolated leukocytes, hepatomegaly, myopathy, cataracts, neurosensory hearing loss and developmental delay. The disorder presents at birth with generalized, fine, white scaling of the skin and a variable degree of erythema resembling non-bullous congenital ichthyosiform erythroderma.
  • Sequence similaritiesBelongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
  • Developmental stageDetected in fetal epidermis from 49 to 135 days estimated gestational age (at protein level).
  • DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Cellular localizationCytoplasm. Lipid droplet. Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA.

    • Target information above from: UniProt accession Q8WTS1 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for Abhd5 peptide (ab89382)

    ab89382 has not yet been referenced specifically in any publications.

    Publishing research using ab89382 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab89382 Submit a Question for ab89382

    There are currently no Abreviews or Questions for ab89382.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"