You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameAc-TVASSSTA Octapeptide peptide
  • Protein descriptionAc-TVASSSTA Octapeptide; MWt 765 Da.

    • Properties

  • Purification notesPurity: >85% by HPLC
  • FormLyophilised:Hydrate in 0.5ml of H2O.
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.1M Sodium chloride, 0.1M HEPES, pH 7.4
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab95132 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    MS MS: Use at an assay dependent dilution.
    Functional Studies FuncS: Use at an assay dependent dilution.

    Protein info

  • RelevanceAc-TVASSSTA is an Octapeptide mimic of the N-terminal residues of the reactive center loop of PAI-1 (cf. P14-P7 residues). The Octapeptide inactivates PAI-1 by substituting for strand 4 in beta-sheet A in a manner that competes with formation of the latent species. Insertion of the peptide into beta-sheet A effectively forms a stable complex that converts PAI-1 into a substrate for tissue-type plasminogen activator (tPA) and other target proteinases. The resulting species of PAI-1 is thermodynamically stable and is useful for investigating the role of reactive center loop insertion.

    • Ac-TVASSSTA Octapeptide peptide images

    • Mass Spectrometry - Ac-TVASSSTA Octapeptide peptide (ab95132)
      Mass Spectrometry - Ac-TVASSSTA Octapeptide peptide (ab95132)
      Mass spectrometry analysis of ab95132
    • HPLC - Ac-TVASSSTA Octapeptide peptide (ab95132)
      HPLC - Ac-TVASSSTA Octapeptide peptide (ab95132)
      HPLC analysis of ab95132
    • Functional Studies - Ac-TVASSSTA Octapeptide peptide (ab95132)
      Functional Studies - Ac-TVASSSTA Octapeptide peptide (ab95132)
      10% SDS-PAGE Reduced

      Lane 1: PAI-1 (5 ug) Frozen
      Lane 2: PAI-1 (5 ug) Incubated
      Lane 3: PAI-1 (5 ug) + ab95132 (3 ug) Incubated
      Lane 4: PAI-1 (5 ug) Frozen + tPA (0.07 ug)
      Lane 5: PAI-1 (5 ug) Incubated + tPA (0.07 ug)
      Lane 6: PAI-1 (5 ug) + ab95132 (3 ug) Incubated + tPA (0.07 ug)
      Lane 7: Molecular weight markers

    References for Ac-TVASSSTA Octapeptide peptide (ab95132)

    ab95132 has not yet been referenced specifically in any publications.

    Publishing research using ab95132 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab95132 Submit a Question for ab95132

    There are currently no Abreviews or Questions for ab95132.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"