Anti-Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody (ab80052)

Overview

• Product nameAnti-Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibodySee all Acetyl Coenzyme A carboxylase alpha primary antibodies ...
• Description
  Rabbit polyclonal to Acetyl Coenzyme A carboxylase alpha (phospho S1263)
• SpecificityReacts specifically with human Acetyl Coenzyme A carboxylase alpha phosphorylated form S1263, does not react with the non phosphorylated protein.
• Tested applicationsIHC-P, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic Acetyl Coenzyme A carboxylase alpha peptide (Human) conjugated to KLH and phosphorylated at serine 1263.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: Whole serum
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Fatty acid oxidation

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Integration of energy

  • Metabolism
  • Types of disease
  • Cancer

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Integration of energy metabolism

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids and lipoproteins

  • Signal Transduction
  • Metabolism
  • Mitochondrial

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Cardiovascular
  • Lipids / Lipoproteins
  • Fatty Acids
  • Synthesis

Applications

Target

• FunctionCatalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
• Tissue specificityExpressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
• PathwayLipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
• Involvement in diseaseDefects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:200350]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.
• Sequence similaritiesContains 1 ATP-grasp domain.
  Contains 1 biotin carboxylation domain.
  Contains 1 biotinyl-binding domain.
  Contains 1 carboxyltransferase domain.
• Post-translational
  modificationsPhosphorylation on Ser-1263 is required for interaction with BRCA1.
• Cellular localizationCytoplasm.

Target information above from: UniProt accession Q13085 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 32 Human
  • Entrez Gene: 31 Human
  • Entrez Gene: 31 Human
  • Omim: 200350 Human
  • SwissProt: O00763 Human
  • SwissProt: Q13085 Human
  • SwissProt: Q13085 Human
  • Unigene: 234898 Human

  • Unigene: 160556 Human

  see all

• Alternative names
  ACAC antibodyACACA antibodyACACA antibody

  ACACA_HUMAN antibodyACC alpha antibodyACC-alpha antibodyACC1 antibodyACC1 antibodyACCA antibodyAcetyl Coenzyme A antibodyBiotin carboxylase antibody

  see all