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Anti-Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody (ab80052)

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Overview

Product name

Anti-Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody
See all Acetyl Coenzyme A carboxylase alpha products (5) ...

Description

Rabbit polyclonal to Acetyl Coenzyme A carboxylase alpha (phospho S1263)

Specificity

Reacts specifically with human Acetyl Coenzyme A carboxylase alpha phosphorylated form S1263, does not react with the non phosphorylated protein.

Tested applications

IHC-P, WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Synthetic Acetyl Coenzyme A carboxylase alpha peptide (Human) conjugated to KLH and phosphorylated at serine 1263.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Signal Transduction >> Metabolism >> Lipid metabolism
Signal Transduction >> Metabolism >> Mitochondrial
Cardiovascular >> Lipids / Lipoproteins >> Fatty Acids >> Synthesis

Applications

Show applications key

Our Abpromise guarantee covers the use of ab80052 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-P

     IHC-P: 1/50 - 1/200.

    IHC-P: 1/50 - 1/200.

  • ShowHide

    WB

     WB: 1/200 - 1/1000.Predi...Read more →

    WB: 1/200 - 1/1000.Predicted molecular weight: 266 kDa.

Target

Function

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Tissue specificity

Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.

Involvement in disease

Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:200350]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.

Sequence similarities

Contains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain.

Post-translational
modifications

Phosphorylation on Ser-1263 is required for interaction with BRCA1.

Cellular localization

Cytoplasm.

Target information above from: UniProt accessionQ13085 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ACAC antibody
  • ACACA antibody
  • ACC alpha antibody
  • ACC1 antibody
  • ACCA antibody
  • ACACA antibody
  • ACACA_HUMAN antibody
  • ACC-alpha antibody
  • ACC1 antibody
  • Acetyl Coenzyme A antibody
  • Biotin carboxylase antibody
see all

Database links

References for Anti-Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody (ab80052)

ab80052 has not yet been referenced specifically in any publications.

Publishing research using ab80052? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"