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Product Name
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Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody
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See all Acetyl Coenzyme A carboxylase alpha antibodies (4)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Acetyl Coenzyme A carboxylase alpha (phospho S1263)
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Immunogen
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Synthetic Acetyl Coenzyme A carboxylase alpha peptide (Human) conjugated to KLH and phosphorylated at serine 1263.
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Reacts with
(species key)
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Hu
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Specificity
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Reacts specifically with human Acetyl Coenzyme A carboxylase alpha phosphorylated form S1263, does not react with the non phosphorylated protein.
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Tested applications
(see key)
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IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: 1/50 - 1/200.
WB: 1/200 - 1/1000. Predicted molecular weight: 266 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasmic
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Research areas
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Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Signal Transduction >> Metabolism >> Lipid metabolism
Signal Transduction >> Metabolism >> Mitochondrial
Cardiovascular >> Lipids / Lipoproteins >> Fatty Acids >> Synthesis
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Relevance
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Acetyl Coenzyme A carboxylase alpha catalyzes the carboxylation of acetyl CoA to form malonyl CoA, the rate limiting step in the biogenesis of LCFA CoA. ACC1 carries three functions: biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase (catalytic activity). Two variants of ACC1 have been described. One with 8 additional amino acids commencing at Pro 1196. The other which is 59aa shorter than the predominant fat and liver isoform exist in mammals. The presence of 8 additional amino acids inhibits the in vitro phosphorylation of the Ser1200 by cAMP dependent kinase. The two ACC1 isoforms are differentially regulated in a tissue specific manner and under different physiological conditions. The activity of ACC1 is finely regulated by hormone dependent phosphorylation and dephosphorylation.
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Alternative names Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody (ab80052) |
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 31 (Human)
| Omim | | 200350 (Human)
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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Preservative: None
Constituents: Whole serum
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Acetyl Coenzyme A carboxylase alpha
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