Anti-Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody (ab80052)

Overview

  • Product nameAnti-Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibodySee all Acetyl Coenzyme A carboxylase alpha primary antibodies ...
  • Description
    Rabbit polyclonal to Acetyl Coenzyme A carboxylase alpha (phospho S1263)
  • SpecificityReacts specifically with human Acetyl Coenzyme A carboxylase alpha phosphorylated form S1263, does not react with the non phosphorylated protein.
  • Tested applicationsIHC-P, WB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic Acetyl Coenzyme A carboxylase alpha peptide (Human) conjugated to KLH and phosphorylated at serine 1263.

Applications

Our Abpromise guarantee covers the use of ab80052 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P 1/50 - 1/200.
WB 1/200 - 1/1000. Predicted molecular weight: 266 kDa.

Target

  • FunctionCatalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
  • Tissue specificityExpressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
  • PathwayLipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
  • Involvement in diseaseDefects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:200350]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.
  • Sequence similaritiesContains 1 ATP-grasp domain.
    Contains 1 biotin carboxylation domain.
    Contains 1 biotinyl-binding domain.
    Contains 1 carboxyltransferase domain.
  • Post-translational
    modifications
    Phosphorylation on Ser-1263 is required for interaction with BRCA1.
  • Cellular localizationCytoplasm.
  • Target information above from: UniProt accession Q13085 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • ACAC antibody
    • ACACA antibody
    • ACACA antibody
    • ACACA_HUMAN antibody
    • ACC alpha antibody
    • ACC-alpha antibody
    • ACC1 antibody
    • ACC1 antibody
    • ACCA antibody
    • Acetyl Coenzyme A antibody
    • Biotin carboxylase antibody
    see all

References for Anti-Acetyl Coenzyme A carboxylase alpha (phospho S1263) antibody (ab80052)

ab80052 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab80052.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"