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Products:Cardiovascular >> Blood >> Other
Overview
Product name
Anti-Aconitase 1 antibody
See all Aconitase 1 products (8) ...
Description
Mouse monoclonal to Aconitase 1
Tested applications
Cross reactivity
Reacts with
Recombinant Fragment
Predicted to work with
Human
Immunogen
Recombinant fragment, corresponding to amino acids 780-890 of Human Aconitase 1
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
Signal Transduction >> Metabolism >> Vitamins / Minerals
Epigenetics and Nuclear Signaling >> DNA / RNA >> RNA Processing >> Other
Signal Transduction >> Metabolism >> Energy Metabolism
Cardiovascular >> Blood >> Other
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Western blot - Aconitase 1 antibody (ab54718)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab54718 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Sequence similarities
Belongs to the aconitase/IPM isomerase family.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionP21399
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ACO 1 antibody
- ACO1 antibody
- ACOC_HUMAN antibody
see all
Database links
- Entrez Gene: 48 Human
- Omim: 100880 Human
- SwissProt: P21399 Human
- Unigene: 567229 Human
Anti-Aconitase 1 antibody images:
Western blot - Aconitase 1 antibody (ab54718)
Western blot against tagged recombinant protein immunogen using ab54718 Aconitase 1 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
References for Anti-Aconitase 1 antibody (ab54718)
ab54718 has not yet been referenced specifically in any publications.
Publishing research using ab54718? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"