You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameAconitase 1 protein
  • Protein descriptionRecombinant full length Human Aconitase 1 (amino acids 1-889) with N terminal His tag; 912 amino acids with tag, MWt 100.8 kDa (UniProt P21399).
  • Uniprot accessionP21399
  • Molecular weight100.800kDa inclusive of tags
  • Protein length889 amino acids
  • Expression hostE. coli

    • Properties

  • Purity> 90 % by SDS-PAGE
  • Purification notesab103501 was purified using conventional chromatography techniques.
  • E.C. Number4.2.1.3
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 2mM DTT, 100mM Sodium chloride, pH 8.0
  • Concentration information loading...
  • SequenceMGSSHHHHHHSSGLVPRGSHMGSMSNPFAHLAEPLDPVQP GKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKK QDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDF AAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRAD SLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGII HQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGIL GWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTS TDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIA NMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYL QAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQ DKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIY DNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAV DAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFD VVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRN FEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGV NAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIE TVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQ PPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLT NRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQ APQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAG SSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLE YLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGK TFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab103501 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
  • Application notesThis peptide can be used with studies using ab154548.

    • Protein info

    • Alternative names
        ACO 1ACO1ACOC_HUMAN
        AconitaseAconitase 1 solubleAconitase1Aconitate hydrataseACONSCitrate hydro lyaseCitrate hydro-lyaseCytoplasmic aconitate hydrataseFerritin repressor proteinIRE BP 1IRE-BP 1IREB 1IREB1IREBPIREBP1Iron regulatory protein 1Iron responsive element binding protein 1Iron-responsive element-binding protein 1IRP 1IRP1OTTHUMP00000045233
      see all
  • FunctionIron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
    Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
  • Sequence similaritiesBelongs to the aconitase/IPM isomerase family.
  • Cellular localizationCytoplasm.

    • Target information above from: UniProt accession P21399 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Aconitase 1 protein images

    • SDS-PAGE - Aconitase 1 protein (ab103501)
      SDS-PAGE - Aconitase 1 protein (ab103501)
      15% SDS-PAGE analysis of 3µg ab103501.

    References for Aconitase 1 protein (ab103501)

    ab103501 has not yet been referenced specifically in any publications.

    Publishing research using ab103501 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab103501 Submit a Question for ab103501

    There are currently no Abreviews or Questions for ab103501.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"