Active human eIF4EBP1 peptide (ab39917)
Key features and details
- Active: Yes
- Suitable for: Blocking
Description
-
Product name
Active human eIF4EBP1 peptide
See all eIF4EBP1 proteins and peptides -
Biological activity
blocking the activity of RPS6K1 antibody (ab25872). -
Animal free
No -
Nature
Synthetic -
-
Species
Human
-
Specifications
Our Abpromise guarantee covers the use of ab39917 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
Applications
Blocking
-
Form
Liquid -
Concentration information loading...
Preparation and Storage
-
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSAThis product is an active protein and may elicit a biological response in vivo, handle with caution.
General Info
-
Alternative names
- 4E-BP1
- 4EBP1
- 4EBP1_HUMAN
see all -
Function
Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. -
Sequence similarities
Belongs to the eIF4E-binding protein family. -
Post-translational
modificationsPhosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
-
Datasheet download
References (1)
ab39917 has been referenced in 1 publication.
- Col E et al. Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock. Sci Rep 7:5418 (2017). PubMed: 28710461