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Product name
Anti-Activin A Receptor Type IB antibody [RM0070-6J28]
See all Activin A Receptor Type IB products (8) ...
Description
Rat monoclonal [RM0070-6J28] to Activin A Receptor Type IB
Specificity
ab86470 detects mouse Activin A Receptor Type IB, but not Activin receptor type 1 (ALK2)
Tested applications
Cross reactivity
Reacts with
Mouse
Immunogen
Extracellular domain of Mouse recombinant Activin A Receptor Type IB protein
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Purification notes
IgG fraction of cell culture supernatant purified by Protein A/G affinity chromatography and 0.2 µm filtered.
Clonality
Monoclonal
Clone number
RM0070-6J28
Isotype
IgG2
Research areas
Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microfilaments >> Actin etc >> Actin Binding Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab86470 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000. Predicted molecular weight: 57 kDa.
Target
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
Tissue specificity
Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
Post-translational
modifications
Autophosphorylated.
Cellular localization
Membrane.
Target information above from: UniProt accessionP36896
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Form
There are 3 isoforms produced by alternative splicing. Isoform 1 also known as SKR2-1; isoform 2 as SKR2-2; isoform 3 as SKR2-3.
Alternative names
- Activin A receptor type 1B antibody
- Activin A receptor type II like kinase 4 antibody
- Activin A type 1B receptor antibody
see all
Database links
- Entrez Gene: 11479 Mouse
- SwissProt: Q61271 Mouse
- Unigene: 308467 Mouse
References for Anti-Activin A Receptor Type IB antibody [RM0070-6J28] (ab86470)
ab86470 has not yet been referenced specifically in any publications.
Publishing research using ab86470? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"