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- Secondary antibodies
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Product name
Anti-Activin A Receptor Type IB antibody
See all Activin A Receptor Type IB products (8) ...
Description
Rabbit polyclonal to Activin A Receptor Type IB
Specificity
This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.
Tested applications
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide (Human); 14 amino acid peptide from near the C terminus of Activin A Receptor Type IB.
Positive control
Human kidney tissue lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microfilaments >> Actin etc >> Actin Binding Proteins
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Western blot - Activin A Receptor Type IB antibody (ab77049)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab77049 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa.
Target
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
Tissue specificity
Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
Post-translational
modifications
Autophosphorylated.
Cellular localization
Membrane.
Target information above from: UniProt accessionP36896
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Form
There are 3 isoforms produced by alternative splicing. Isoform 1 also known as SKR2-1; isoform 2 as SKR2-2; isoform 3 as SKR2-3.
Alternative names
- Activin A receptor type 1B antibody
- Activin A receptor type II like kinase 4 antibody
- Activin A type 1B receptor antibody
see all
Database links
- Entrez Gene: 91 Human
- Entrez Gene: 11479 Mouse
- Omim: 601300 Human
- SwissProt: P36896 Human
- SwissProt: Q61271 Mouse
- Unigene: 438918 Human
- Unigene: 308467 Mouse
Anti-Activin A Receptor Type IB antibody images:
Western blot - Activin A Receptor Type IB antibody (ab77049)
All lanes : Anti-Activin A Receptor Type IB antibody (ab77049) at 1 µg/ml
Lane 1 : human kidney tissue lysate
Lane 2 : human kidney tissue lysate with blocking peptide
Lysates/proteins at 15 µg per lane.
Predicted band size : 57 kDa
Observed band size : 66 kDa (why is the actual band size different from the predicted?)
References for Anti-Activin A Receptor Type IB antibody (ab77049)
ab77049 has not yet been referenced specifically in any publications.
Publishing research using ab77049? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"