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Activin A Receptor Type IB protein (Active) (ab55682)

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Overview

  • Product nameActivin A Receptor Type IB protein (Active)See all Activin A Receptor Type IB proteins and peptides ...
  • Protein descriptionRecombinant fragment corresponding to amino acids 150-end of Human Activin A Receptor Type IB, with a N terminal tag
  • Expression hostBaculovirus infected sf9 cells

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesab55682 purity was determined by densitometry.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab55682 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies
    SDS-PAGE
  • Application notesFuncS: Kinase assay: Use at an assay dependent dilution.
    SDS-PAGE: Use at an assay dependent dilution.

    Specific activity: 16 nmol/min/mg

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        Activin A receptor type 1BActivin A receptor type II like kinase 4Activin A type 1B receptor
        Activin A type IB receptorActivin receptor like kinase 4Activin receptor type 1BActivin receptor type IBActivin receptor type-1BActivin receptor-like kinase 4ACTR IBACTR-IBACTRIBACV1B_HUMANACVR 1BACVR1BACVRLK 4ACVRLK4ALK 4ALK-4ALK4Serine(threonine) protein kinase receptor R2Serine/threonine-protein kinase receptor R2SKR 2SKR2
      see all
  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
  • Tissue specificityExpressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications    Autophosphorylated.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P36896 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Activin A Receptor Type IB protein (Active) images

    • Functional Studies - Activin A Receptor Type IB protein (Active) (ab55682)
      Functional Studies - Activin A Receptor Type IB protein (Active) (ab55682)
      Sample Kinase Activity assay plot, using ab55682.
    • SDS-PAGE - Activin A Receptor Type IB protein (Active) (ab55682)
      SDS-PAGE - Activin A Receptor Type IB protein (Active) (ab55682)
      Sample purity data showing SDS-PAGE analysis of ab55682, with molecular weight markers.

    References for Activin A Receptor Type IB protein (Active) (ab55682)

    ab55682 has not yet been referenced specifically in any publications.

    Publishing research using ab55682 ? Please let us know so that we can cite the reference in this datasheet

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