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Activin A Receptor Type IC protein (ab125628)

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Overview

  • Product nameActivin A Receptor Type IC proteinSee all Activin A Receptor Type IC proteins and peptides ...
  • Protein descriptionRecombinant fragment of Human Activin A Receptor Type IC (amino acids 135-493) with N-terminal proprietary tag, MW 68kDa (UniProt Q8NER5).
  • Uniprot accessionQ8NER5
  • Molecular weight68kDa inclusive of tags
  • Protein length359 amino acids
  • Expression hostBaculovirus infected sf9 cells

    • Properties

  • Purification notes>75% by Densitometry
  • E.C. Number2.7.11.30
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab125628 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Activin A receptor, type ICActivin receptor like kinase 7Activin receptor type 1C precursor
        Activin receptor type ICActivin receptor type-1CActivin receptor-like kinase 7ACTR ICACTR-ICACTRICACV1C_HUMANAcvr1cACVRLK7ALK 7ALK-7ALK7
      see all
  • FunctionSerine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
  • Tissue specificityPresent in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession Q8NER5 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Activin A Receptor Type IC protein images

    • SDS-PAGE - Activin A Receptor Type IC protein (ab125628)
      SDS-PAGE - Activin A Receptor Type IC protein (ab125628)
      SDS-PAGE of Human Activin A Receptor Type IC.

    References for Activin A Receptor Type IC protein (ab125628)

    ab125628 has not yet been referenced specifically in any publications.

    Publishing research using ab125628 ? Please let us know so that we can cite the reference in this datasheet

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