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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Activin Receptor Type IA antibody (ab60157)

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Product Name
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Activin Receptor Type IA antibody
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See all Activin Receptor Type IA antibodies (7)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Activin Receptor Type IA
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Immunogen
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KLH conjugated synthetic peptide from the central region of human Activin Receptor Type IA.
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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ELISA, IHC-P
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Abreviews
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Application notes
(see key)
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Recommended dilutions ELISA: 1/1000. IHC-P: 1/50 - 1/100.
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Human hepatocarcinoma tissue
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Cellular localization
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Single pass type I membrane protein
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Research areas
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Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> SMADs Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> Structures >> Bone Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microfilaments >> Actin etc >> Actin Binding Proteins
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Relevance
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Activin Receptor Type IA on ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Activin receptor IA is highly conserved and is a receptor for BMP2 and BMP4.
Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of cytokines and hormones inlude activin, Anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal. They are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions. There are three type I Activin receptors:ACVR1, ACVR1B, and ACVR1C Each bind to a specific type II receptor-ligand complex. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a Type two receptor, which recruits and trans-phosphorylate a type I receptor. The type I receptor recruits a receptor regulated SMAD (R-SMAD) which it phosphorylates. The RSMAD then translocates to the nucleus where it functions as a transcription factor.
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 90 (Human)
| Omim | | 102576 (Human)
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Ammonium Sulphate Precipitation
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Storage buffer
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Preservative: 0.09% Sodium Azide Constituents: PBS Material safety datasheet (MSDS) for this product: Sodium Azide MSDS
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Purification notes
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Prepared by Saturated Ammonium Sulfate (SAS) precipitation, followed by dialysis against PBS.
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Form
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Liquid
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Concentration
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0.250 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C. Store in the dark. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Activin Receptor Type IA antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Activin Receptor Type IA antibody images:
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Activin Receptor Type IA antibody (ab60157)
ab60157, at a 1/50-1/100 dilution, staining Activin Receptor Type IA in human hepatocarcinoma on Formalin fixed Paraffin embedded tissue. A peroxidase-conjugated secondary antibody was used, followed by AEC staining.
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Search PubMed (MEDLINE) for references to Activin Receptor Type IA
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