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Activin Receptor Type IA protein (Active) (ab84539)

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Overview

  • Product nameActivin Receptor Type IA protein (Active)See all Activin Receptor Type IA proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to the cytoplasmic domain (amino acids 147-509) of Human Activin Receptor Type IA, expressed by baculovirus in Sf9 insect cells, with an N terminal proprietary tag. NM_001105 This peptide was used as an immunogen for ab10592 - Activin Receptor Type IA antibody.
  • Expression hostBaculovirus infected sf9 cells

    • Properties

  • Purity> 90 % by SDS-PAGE
  • Biological activityThe specific activity of Activin Receptor Type IA was determined to be 46 nmol/min/mg by activity assay.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Sequence notesLLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN SLDKLKTD
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab84539 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
    Functional Studies
    SDS-PAGE
  • Application notesKinase Assay: Use at an assay dependent dilution.
    SDS-PAGE: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 57 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        Activin A receptor type IActivin A receptor type II like kinase 2Activin receptor type I
        Activin receptor type-1Activin receptor-like kinase 2ACTR-IACTRIACVR1ACVR1_HUMANACVR1AACVRLK2ALK 2ALK-2ALK2FOPHydroxyalkyl protein kinaseSerine/threonine-protein kinase receptor R1SKR1TGF-B superfamily receptor type ITGFB superfamily receptor type ITSR-ITSRI
      see all
  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.
  • Tissue specificityExpressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
  • Involvement in diseaseDefects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession Q04771 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Activin Receptor Type IA protein (Active) images

    • Functional Studies - Activin Receptor Type IA protein (Active) (ab84539)
      Functional Studies - Activin Receptor Type IA protein (Active) (ab84539)
      The specific activity of ab84539 was determined to be 46 nmol/min/mg by activity assay.
    • SDS-PAGE - Activin Receptor Type IA protein (Active) (ab84539)
      SDS-PAGE - Activin Receptor Type IA protein (Active) (ab84539)
      The purity of ab84539 was determined to be >90% by SDS-PAGE. Molecular Weight: 67 kDa.

    References for Activin Receptor Type IA protein (Active) (ab84539)

    ab84539 has not yet been referenced specifically in any publications.

    Publishing research using ab84539 ? Please let us know so that we can cite the reference in this datasheet

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