Anti-Activin Receptor Type IIA antibody (ab216960)

Overview

  • Product name
    Anti-Activin Receptor Type IIA antibody
    See all Activin Receptor Type IIA primary antibodies
  • Description
    Rabbit polyclonal to Activin Receptor Type IIA
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide within Human Activin Receptor Type IIA aa 20-70 (extracellular) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: P27037

  • Positive control
    • Mouse testis and mouse brain lysates; rat brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab216960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/1000. Predicted molecular weight: 58 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
  • Sequence similarities
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activin A receptor type IIA antibody
    • Activin receptor type 2A antibody
    • Activin receptor type IIA antibody
    • Activin receptor type-2A antibody
    • ACTR 2 antibody
    • ACTR IIA antibody
    • ACTR-IIA antibody
    • ACTR2 antibody
    • ACTRII antibody
    • ACTRIIA antibody
    • Acvr 2 antibody
    • Acvr 2A antibody
    • Acvr2 antibody
    • ACVR2A antibody
    • AVR2A_HUMAN antibody
    • OTTHUMP00000197918 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling Activin Receptor Type IIA with ab216960 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

  • All lanes : Anti-Activin Receptor Type IIA antibody (ab216960) at 1/200 dilution

    Lane 1 : mouse testis lysate
    Lane 2 : mouse brain lysate

    Secondary
    Lane 1 : HRP-conjugated secondary antibody at 1/3000 dilution
    Lane 2 : Goat Anti-Rabbit IgG Antibody (H+L), HRP conjugated, 90 min in 37°C at 1/3000 dilution

    Predicted band size: 58 kDa



    12% SDS-PAGE

References

ab216960 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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