On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling Activin Receptor Type IIA with ab216960 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
Western blot - Anti-Activin Receptor Type IIA antibody (ab216960)
All lanes : Anti-Activin Receptor Type IIA antibody (ab216960) at 1/200 dilution
Lane 1 : mouse testis lysate Lane 2 : mouse brain lysate
Secondary Lane 1 : HRP-conjugated secondary antibody at 1/3000 dilution Lane 2 : Goat Anti-Rabbit IgG Antibody (H+L), HRP conjugated, 90 min in 37°C at 1/3000 dilution