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Activin Receptor Type IIA protein (ab114448)

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Overview

  • Product nameActivin Receptor Type IIA proteinSee all Activin Receptor Type IIA proteins and peptides ...
  • Protein descriptionRecombinant full length Human Activin Receptor Type IIA (amino acids 1-513) with N terminal proprietary tag; Predicted MWt 82.50 kDa (AAH67418.1).
  • Uniprot accessionP27037
  • Molecular weight82.500kDa inclusive of tags
  • Protein length513 amino acids
  • Expression hostWheat germ

    • Properties

  • E.C. Number2.7.11.30
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Sequence notesMGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKD RTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWL DDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWV YRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKAR GRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLK ANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISH RDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASR CTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPV LRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab114448 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    WB WB: Use at an assay dependent concentration.

    Protein info

    • Alternative names
        Activin A receptor type IIAActivin receptor type 2AActivin receptor type IIA
        Activin receptor type-2AACTR 2ACTR IIAACTR-IIAACTR2ACTRIIACTRIIAAcvr 2Acvr 2AAcvr2ACVR2AAVR2A_HUMANOTTHUMP00000197918
      see all
  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P27037 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Activin Receptor Type IIA protein images

    • SDS-PAGE - Activin Receptor Type IIA protein (ab114448)
      SDS-PAGE - Activin Receptor Type IIA protein (ab114448)
      ab114448 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

    References for Activin Receptor Type IIA protein (ab114448)

    ab114448 has not yet been referenced specifically in any publications.

    Publishing research using ab114448 ? Please let us know so that we can cite the reference in this datasheet

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