Anti-Activin Receptor Type IIB antibody (ab116315)

Overview

  • Product nameAnti-Activin Receptor Type IIB antibody
    See all Activin Receptor Type IIB primary antibodies
  • Description
    Rabbit polyclonal to Activin Receptor Type IIB
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 147-176 of Mouse Activin Receptor Type IIB (NP_031423.1).

  • Positive control
    • NCI-H460 cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab116315 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 61 kDa.

Target

  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
  • Involvement in diseaseDefects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4) [MIM:613751]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy type 4 include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activin A receptor type IIB antibody
    • Activin receptor type 2B antibody
    • Activin receptor type IIB antibody
    • Activin receptor type-2B antibody
    • ActR IIB antibody
    • ACTR-IIB antibody
    • ActRIIB antibody
    • ACVR 2B antibody
    • ACVR2B antibody
    • AVR2B_HUMAN antibody
    • HTX4 antibody
    • MGC116908 antibody
    see all

Anti-Activin Receptor Type IIB antibody images

  • Anti-Activin Receptor Type IIB antibody (ab116315) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

    Predicted band size : 61 kDa

References for Anti-Activin Receptor Type IIB antibody (ab116315)

ab116315 has not yet been referenced specifically in any publications.

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