Anti-Activin Receptor Type IIB antibody (ab116315)

Overview

• Product nameAnti-Activin Receptor Type IIB antibodySee all Activin Receptor Type IIB primary antibodies ...
• Description
  Rabbit polyclonal to Activin Receptor Type IIB
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse
• Immunogen

  Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 147-176 of Mouse Activin Receptor Type IIB (NP_031423.1).

• Positive controlNCI-H460 cell line lysates.

Properties

• FormLiquid
• Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
• Storage bufferPreservative: 0.09% Sodium azide
  Constituent: 99% PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab116315 is purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Stem Cells
  • Signaling Pathways
  • TGF beta
  • Surface Molecules

  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Microfilaments
  • Actin etc
  • Actin Binding Proteins

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • Other Kinases

Applications

Target

• FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
• Involvement in diseaseDefects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4) [MIM:613751]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy type 4 include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver.
• Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
  Contains 1 protein kinase domain.
• Cellular localizationMembrane.

Target information above from: UniProt accession Q13705 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 93 Human
  • Entrez Gene: 11481 Mouse
  • Omim: 602730 Human
  • SwissProt: Q13705 Human
  • SwissProt: P27040 Mouse
  • Unigene: 174273 Human
  • Unigene: 390239 Mouse

• Alternative names
  Activin A receptor type IIB antibodyActivin receptor type 2B antibodyActivin receptor type IIB antibody

  Activin receptor type-2B antibodyActR IIB antibodyACTR-IIB antibodyActRIIB antibodyACVR 2B antibodyACVR2B antibodyAVR2B_HUMAN antibodyHTX4 antibodyMGC116908 antibody

  see all

Anti-Activin Receptor Type IIB antibody images

• 

  Western blot - Anti-Activin Receptor Type IIB antibody (ab116315)
  Anti-Activin Receptor Type IIB antibody (ab116315) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg
  
  Predicted band size : 61 kDa