Anti-Activin Receptor Type IIB/ACVR2B antibody (ab128544)
Key features and details
- Rabbit polyclonal to Activin Receptor Type IIB/ACVR2B
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
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- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Activin Receptor Type IIB/ACVR2B antibody
See all Activin Receptor Type IIB/ACVR2B primary antibodies -
Description
Rabbit polyclonal to Activin Receptor Type IIB/ACVR2B -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Recombinant fragment corresponding to Human Activin Receptor Type IIB/ACVR2B aa 22-264. (BC096243)
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Positive control
- K562 and PANC-1 cell lysates, Human fetal brain tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab128544 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/1000 - 1/2000. Predicted molecular weight: 58 kDa.
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IHC-P |
1/100 - 1/500.
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Notes |
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WB
1/1000 - 1/2000. Predicted molecular weight: 58 kDa. |
IHC-P
1/100 - 1/500. |
Target
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Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. -
Involvement in disease
Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4) [MIM:613751]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy type 4 include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver. -
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 93 Human
- Entrez Gene: 11481 Mouse
- Omim: 602730 Human
- SwissProt: Q13705 Human
- SwissProt: P27040 Mouse
- Unigene: 174273 Human
- Unigene: 390239 Mouse
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Alternative names
- Activin A receptor type IIB antibody
- Activin receptor type 2B antibody
- Activin receptor type IIB antibody
see all
Images
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All lanes : Anti-Activin Receptor Type IIB/ACVR2B antibody (ab128544) at 1/1000 dilution
Lane 1 : K562 cell lysate
Lane 2 : PANC-1 cell lysate
Predicted band size: 58 kDa -
ab128544, at a dilution of 1/100, staining Activin Receptor Type IIB/ACVR2B in paraffin-embedded Human fetal brain tissue by Immunohistochemistry.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab128544 has been referenced in 5 publications.
- Feng B et al. Upregulation of Extracellular Vesicles-Encapsulated miR-132 Released From Mesenchymal Stem Cells Attenuates Ischemic Neuronal Injury by Inhibiting Smad2/c-jun Pathway via Acvr2b Suppression. Front Cell Dev Biol 8:568304 (2020). PubMed: 33763412
- Petrusel L et al. Relationship between cachexia and perineural invasion in pancreatic adenocarcinoma. World J Gastrointest Oncol 11:1126-1140 (2019). PubMed: 31908718
- Castillero E et al. Structural and functional cardiac profile after prolonged duration of mechanical unloading: potential implications for myocardial recovery. Am J Physiol Heart Circ Physiol 315:H1463-H1476 (2018). PubMed: 30141986
- Lin TT et al. Follicular localization of growth differentiation factor 8 and its receptors in normal and polycystic ovary syndrome ovaries. Biol Reprod 98:683-694 (2018). PubMed: 29409020
- Galvão A et al. Nodal Promotes Functional Luteolysis via Down-Regulation of Progesterone and Prostaglandins E2 and Promotion of PGF2a Synthetic Pathways in Mare Corpus Luteum. Endocrinology 157:858-71 (2016). PubMed: 26653568