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Anti-Activin Receptor Type IIB antibody (ab99070)

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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab99070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
  • Involvement in diseaseDefects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4) [MIM:613751]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy type 4 include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession Q13705 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Activin A receptor type IIB antibodyActivin receptor type 2B antibodyActivin receptor type IIB antibody
        Activin receptor type-2B antibodyActR IIB antibodyACTR-IIB antibodyActRIIB antibodyACVR 2B antibodyACVR2B antibodyAVR2B_HUMAN antibodyHTX4 antibodyMGC116908 antibody
      see all

    Anti-Activin Receptor Type IIB antibody images

    • Western blot - Activin Receptor Type IIB antibody (ab99070)
      Western blot - Activin Receptor Type IIB antibody (ab99070)
      Anti-Activin Receptor Type IIB antibody (ab99070) at 1 µg/ml + PANC1 cell lysate at 10 µg

      Predicted band size : 58 kDa

    References for Anti-Activin Receptor Type IIB antibody (ab99070)

    ab99070 has not yet been referenced specifically in any publications.

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    Western blot abreview for Anti-Activin Receptor Type IIB antibody

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    Abreviews
    Application Western blot
    Sample Human Cell lysate - whole cell (ovarian cancer cell lines)
    Loading amount 45 µg
    Specification ovarian cancer cell lines
    Gel Running Conditions Reduced Denaturing (4-12% NuPAGE gel with MOPS running buffer)
    Blocking step Licor/Oddessey Blocking buffer as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 100% · Temperature: 22°C
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    Submitted Dec 15 2010

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"