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Activin Receptor Type IIB protein (ab114487)

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Overview

  • Product nameActivin Receptor Type IIB proteinSee all Activin Receptor Type IIB proteins and peptides ...
  • Protein descriptionRecombinant full length Human Activin Receptor Type IIB, aa 1-303 according to AAH96245.1, with N terminal proprietary tag; 59.4 incluisive of tag.
  • Molecular weight59.400kDa inclusive of tags
  • Protein length303 amino acids
  • Expression hostWheat germ

    • Properties

  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Sequence notesMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCH VAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLL KSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEV LEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDE YMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPG LAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTT SDCLVSLVTSVTNVDLPPKESSI
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab114487 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    WB WB: Use at an assay dependent concentration. (Recombinant protein).

    Protein info

    • Alternative names
        Activin A receptor type IIBActivin receptor type 2BActivin receptor type IIB
        Activin receptor type-2BActR IIBACTR-IIBActRIIBACVR 2BACVR2BAVR2B_HUMANHTX4MGC116908
      see all
  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
  • Involvement in diseaseDefects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4) [MIM:613751]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy type 4 include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession Q13705 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Activin Receptor Type IIB protein images

    • SDS-PAGE - Activin Receptor Type IIB protein (ab114487)
      SDS-PAGE - Activin Receptor Type IIB protein (ab114487)
      12.5% SDS-PAGE showing ab114487 at approximately 59.40kDa stained with Coomassie Blue.

    References for Activin Receptor Type IIB protein (ab114487)

    ab114487 has not yet been referenced specifically in any publications.

    Publishing research using ab114487 ? Please let us know so that we can cite the reference in this datasheet

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    How much volume do i need to have 200ngl?

    Thank you for calling Abcam earlier today.

    If my calculations are correct, then you would need 1.3ul of ab114487 to get 200ng.

    If there is anything else I can help you with, please let me know.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"