Activin Receptor Type IIA antibody [149/1] - BSA and Azide free (ab18103)

Product Name 

Activin Receptor Type IIA antibody [149/1] - BSA and Azide free

Product type 

Primary antibodies

Description 

Mouse monoclonal [149/1] to Activin Receptor Type IIA - BSA and Azide free

Immunogen 

Recombinant intracellular kinase domain of the human type 2 activin A receptor (ACVR2A).

Reacts with 
(species key)

Hu

Tested applications 
(see key)

IP, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions

IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 57 kDa.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cell Membrane and Cytoplasmic

Research areas 

Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microfilaments >> Actin etc >> Actin Binding Proteins
Signal Transduction >> Metabolism >> Amino Acids

Relevance 

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. Activin has been suggested to be an autocrine/paracrine regulator in the human placenta. The presence of ACVR2 mRNA has been deomnstrated in human trophoblast cells and there is also evidence of expression of the gene in human brain and ovary.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

149/1

Isotype 

IgG1

Purity 

Protein A purified

Storage buffer 

Preservative: None
Constituents: PBS

Form 

Liquid

Concentration 

0.500 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

References for Activin Receptor Type IIA antibody [149/1] - BSA and Azide free (ab18103)

  This product has been used in: (two most recent references)

McCarthy SA et al. Monoclonal antibodies that recognize the type-2 activin receptor, ACTR2. Hybridoma 13:199-203 (1994). PubMed: 7927363

McCarthy SA & Bicknell R Activin-A binds to a heterotrimeric receptor complex on the vascular endothelial cell surface. Evidence for a type 3 activin receptor. J Biol Chem 269:3909-12 (1994). PubMed: 8307945
If you publish research using ab18103 please let us know so that we can cite the reference on this datasheet.

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