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Anti-Activin Receptor Type IIA antibody [149/1] - BSA and Azide free (ab18103)

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Overview

Product name

Anti-Activin Receptor Type IIA antibody [149/1] - BSA and Azide free
See all Activin Receptor Type IIA products (7) ...

Description

Mouse monoclonal [149/1] to Activin Receptor Type IIA - BSA and Azide free

Tested applications

WB, IPmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant intracellular kinase domain of the human type 2 activin A receptor (ACVR2A).

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Monoclonal

Clone number

149/1

Isotype

IgG1

Research areas

Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microfilaments >> Actin etc >> Actin Binding Proteins
Signal Transduction >> Metabolism >> Amino Acids

Applications

Show applications key

Our Abpromise guarantee covers the use of ab18103 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain.

Cellular localization

Membrane.

Target information above from: UniProt accessionP27037 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Activin A receptor type IIA antibody
  • Activin receptor type 2A antibody
  • Activin receptor type IIA antibody
  • Activin receptor type-2A antibody
  • ACTR 2 antibody
  • ACTR IIA antibody
  • ACTR-IIA antibody
  • ACTR2 antibody
  • ACTRII antibody
  • ActRIIa antibody
  • Acvr 2 antibody
  • Acvr 2A antibody
  • Acvr2 antibody
  • Acvr2a antibody
  • AVR2A_HUMAN antibody
  • OTTHUMP00000197918 antibody
see all

Database links

References for Anti-Activin Receptor Type IIA antibody [149/1] - BSA and Azide free (ab18103)

This product has been referenced in:

  • McCarthy SAet al. Monoclonal antibodies that recognize the type-2 activin receptor, ACTR2. Hybridoma 13:199-203 (1994).Read more (PubMed: 7927363) »
  • McCarthy SA & Bicknell R Activin-A binds to a heterotrimeric receptor complex on the vascular endothelial cell surface. Evidence for a type 3 activin receptor. J Biol Chem 269:3909-12 (1994).Read more (PubMed: 8307945) »

See all 2 publications for this product

Publishing research using ab18103? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"