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Overview

  • Product nameAdducin 2 protein (Human)
  • Protein descriptionRecombinant full length Human Adducin 2 (amino acids 1-726) with a N terminal proprietary tag; Predicted MW 105.93 kDa (UniProt: P35612).
  • Uniprot accessionP35612
  • Molecular weight105.930kDa inclusive of tags
  • Protein length726 amino acids
  • Expression hostWheat germ

    • Properties

  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Sequence notesMSEETVPEAASPPPPQGQPYFDRFSEDDPEYMRLRNRAAD LRQDFNLMEQKKRVTMILQSPSFREELEGLIQEQMKKGNN SSNIWALRQIADFMASTSHAVFPTSSMNVSMMTPINDLHT ADSLNLAKGERLMRCKISSVYRLLDLYGWAQLSDTYVTLR VSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSS CFPVDTTGFCLHSAIYAARPDVRCIIHLHTPATAAVSAMK WGLLPVSHNALLVGDMAYYDFNGEMEQEADRINLQKCLGP TCKILVLRNHGVVALGDTVEEAFYKIFHLQAACEIQVSAL SSAGGVENLILLEQEKHRPHEVGSVQWAGSTFGPMQKSRL GEHEFEALMRMLDNLGYRTGYTYRHPFVQEKTKHKSEVEI PATVTAFVFEEDGAPVPALRQHAQKQQKEKTRWLNTPNAY LRVNVADEVQRSMGSPRPKTTWMKADEVEKSSSGMPIRIE NPNQFVPLYTDPQEVLEMRNKIREQNRQDVKSAGPQSQLL ASVIAEKSRSPSTESQLMSKGDEDTKDDSEETVPNPFSQL TDQELEEYKKEVERKKLELDGEKETAPEEPGSPAKSAPAS PVQSPAKEAETKSPLVSPSKSLEEGTKKTETSKAATTEPE TTQPEGVVVNGREEEQTAEEILSKGLSQMTTSADTDVDTS KDKTESVTSGPMSPEGSPSKSPSKKKKKFRTPSFLKKSKK KEKVES
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab116813 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent concentration.
    ELISA ELISA: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
  • Application notesThis peptide can be used with studies using ab94514 and ab151460.

    • Protein info

    • Alternative names
        ADD 2ADD2ADDB
        ADDB_HUMANAdducin 2 (beta)Adducin2Beta adducinBeta-adducinErythrocyte adducin subunit betaOTTHUMP00000203378OTTHUMP00000203908
      see all
  • FunctionMembrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
  • Tissue specificityExpressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K562 cells.
  • Sequence similaritiesBelongs to the aldolase class II family. Adducin subfamily.
  • Developmental stageFetal kidney expresses isoforms 3, 4, 5, 6 and 7, and fetal liver expresses isoforms 3 and 4.
  • DomainEach subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
  • Post-translational
    modifications    The N-terminus is blocked.
  • Cellular localizationCytoplasm > cytoskeleton. Cell membrane.

    • Target information above from: UniProt accession P35612 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Adducin 2 protein (Human) images

    • - Adducin 2 protein (ab116813)
      - Adducin 2 protein (ab116813)
      12.5% SDS-PAGE showing ab116813 at approximately 105.93kDa.
      Stained with Coomassie Blue.

    References for Adducin 2 protein (Human) (ab116813)

    ab116813 has not yet been referenced specifically in any publications.

    Publishing research using ab116813 ? Please let us know so that we can cite the reference in this datasheet

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