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Products:Signal Transduction >> Protein Trafficking >> Organelle Proteins
MSCatalog No. MSA01c
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Read our guarantee »Anti-Adenine Nucleotide Translocase Immunocapture antibody [5F51BB5AG7]
Mouse monoclonal [5F51BB5AG7] to Adenine Nucleotide Translocase Immunocapture
Reacts with
Cow, Human
Recombinant Human Adenine Nucleotide Translocase
Bovine and Human heart mitochondria
Liquid
Store at +4°C. Do not freeze.
Preservative: 0.02% Sodium azide
Constituent: HBS
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ab109864 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.
Monoclonal
5F51BB5AG7
IgG1
kappa
Immunoprecipitation - Adenine Nucleotide Translocase Immunocapture antibody [5F51BB5AG7] (ab109864)
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Our Abpromise guarantee covers the use of ab109864 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at 100 µg/mg of lysate.
ANT is a reversible transporter of ATP and ADP. During oxidative phosphorylation (OXPHOS) the protein exchanges ATP out for ADP in, however, in the absence of OXPHOS ANT works in reverse to maintain mitochondrial membrane potential. A subset of patients with heart related diseases have been shown to harbor mutations in the ANT gene or to develop an autoimmune reaction against the protein. There are a number of proteins found in mitochondria that, under circumstances favoring apoptosis, coalesce to form the so-called permeability transition pore. The proteins identified as a part of the PTP include cytosolic hexokinase, outer membrane porin (also called the voltage dependent anion channel or VDAC), adenylate cyclase in the intermembrane space, the adenine nucleotide transporter (ANT) and the peripheral benzodiazepine receptor protein of the inner membrane along with cyclophilin D of the matrix space. Hexokinase, porin and ANT all occur as isoforms and it remains to be determined whether there is specificity of these different forms for the PTP.
Mitochondrial
Immunoprecipitation - Adenine Nucleotide Translocase Immunocapture antibody [5F51BB5AG7] (ab109864)
![Immunoprecipitation - Adenine Nucleotide Translocase Immunocapture antibody [5F51BB5AG7] (ab109864)](/ps/datasheet/images/109/ab109864/Adenine-Nucleotide-Translocase-Immunocapture-Primary-antibodies-ab109864-1.jpg)
Immunocapture of Adenine Nucleotide Translocase from Bovine heart mitochondria using ab109864 at a concentration of 100 µg/mg lysate.
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