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Product Name
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Adenosine Receptor A2a antibody
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See all Adenosine Receptor A2a antibodies (2)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Adenosine Receptor A2a
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Immunogen
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Synthetic peptide: ESHGDMGLPDVELLSHELK, corresponding to amino acids 373-391 of Dog Adenosine Receptor A2a.
BLAST 'ESHGDMGLPDVELLSHELK' with  or 
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Reacts with
(species key)
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Hu, Dog
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Specificity
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Detects adenosine receptor A2a.
This antibody does not detect other AR subtypes.
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Tested applications
(see key)
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IHC-P, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Immunohistochemistry: 1/100.
Immunoprecipitation: assay dependent.
Western Blot: 1/2000.
Not tested in other applications.
Optimal dilution / concentration should be determined by the end user.
By Western blot, this antibody detects an ~45 kDa protein from canine striatum representing A2aAR.
Immunohistochemical staining of A2aAR in human hippocampus yields a pattern consistent with plasma membrane staining.
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Cellular localization
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Cell Membrane; multi pass membrane protein
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Research areas
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Neuroscience >> Neurology process >> Neuroregeneration >> Neuroregeneration
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Inflammatory mediators
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Cell Biology >> Apoptosis >> Phagocytosis
Cardiovascular >> Blood >> Coagulation >> Regulatory
Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> More GPCR
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Relevance
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This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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PBS, 1 mg/ml BSA and 0.05% sodium azide Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.690 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Adenosine Receptor A2a antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Adenosine Receptor A2a antibody (ab3461)
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This product has been used in:
Buira SP et al. DNA methylation regulates adenosine A(2A) receptor cell surface expression levels. J Neurochem 112:1273-85 (2010). WB; Human. PubMed: 20002525
If you publish research using ab3461 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Adenosine Receptor A2a
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Adenosine Receptor A2a antibody - more information
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