Anti-Adenovirus antibody [M58 + M73] (ab3648)
- Product nameAnti-Adenovirus antibody [M58 + M73]See all Adenovirus primary antibodies ...
- DescriptionMouse monoclonal [M58 + M73] to Adenovirus
- Tested applicationsIHC-P, IHC-Fr, ICC/IF more details
- Positive controlSuitable tissue control sections for Immunohistochemistry: Adenovirus infected tissue.
- Storage instructionsStore at +4°C.
- Storage bufferPreservative: 0.05% Sodium Azide
Constituents: 1% BSA
- Concentration information loading...
- PurityIgG fraction
- Primary antibody notes The adenovirus early gene products E1A is a potent stimulator of cellular proliferation, which when overexpressed can overcome the growth inhibitory effects of TGF beta. The E1A region encodes a series of related proteins (35 - 46 kD) with multifunctional capabilities and forms a specific complex with the retinoblastoma tumor suppressor gene product. The E1a and E1B regions together comprise the transforming region of adenovirus. While expression of E1A alone is sufficient to immortalize primary cells, complete transformation requires the additional expression of the E1B region.
- Clonality Monoclonal
- Clone numberM58 + M73
- Light chain typekappa
- Research Areas
Our Abpromise guarantee covers the use of ab3648 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||IHC-P: 1/50 - 1/75. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. ABC method.|
|IHC-Fr||IHC-Fr: 1/50 - 1/75. ABC method.|
|ICC/IF||ICC/IF: Use at an assay dependent dilution. PubMed: 18287244|
- RelevanceAdenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e. common colds). Forty-seven known serotypes have been isolated since they were first discovered in 1953 with 3 types known to cause gastroenteritis. Several types have oncogenic potential though most cause self-limiting febrile illnesses characterised by inflammation of conjunctivae and the respiratory tract. The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections. It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods. In patients experiencing immunosuppression (e.g. AIDS) it can be reactivated causing disease.
- Adenovirus antibody
References for Anti-Adenovirus antibody [M58 + M73] (ab3648)
This product has been referenced in:
- Magnusson MK et al. A transductionally re-targeted adenovirus vector for virotherapy of Her2/neu expressing prostate cancer. Hum Gene Ther : (2011). IHC-P . Read more (PubMed: 21875358) »
- McSharry BP et al. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. J Virol 82:4585-94 (2008). ICC/IF . Read more (PubMed: 18287244) »